NANS and FLCN

Data Source:
BioGRID (two hybrid)

		NANS	FLCN
Description		N-acetylneuraminate synthase	folliculin
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Cytosol Plasma Membrane Cilium Midbody Cell-cell Contact Zone Mitotic Spindle
	Molecular Function	N-acylneuraminate Cytidylyltransferase Activity N-acylneuraminate-9-phosphate Synthase Activity N-acetylneuraminate Synthase Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein-containing Complex Binding
	Biological Process	CMP-N-acetylneuraminate Biosynthetic Process Carbohydrate Biosynthetic Process Glycosylation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell-cell Junction Assembly Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrion Organization Hemopoiesis Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Regulation Of Cytokinesis Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Regulation Of Histone Acetylation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Regulation Of Pro-B Cell Differentiation Negative Regulation Of ATP Biosynthetic Process
Pathways		Sialic acid metabolism	Amino acids regulate mTORC1
Drugs
Diseases			Renal cell carcinoma Birt-Hogg-Dube syndrome
GWAS		Alopecia areata ( 25608926) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)
Interacting Genes		19 interacting genes: APC AURKA BCL10 BUB1 CDH1 CTNNA1 EGFR FBXO7 FBXW7 FLCN MCC MLH3 MSH6 ODC1 PDGFRL PTPRJ SRC STK11 TLR2	11 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS TMEFF1 TSTD2
Entrez ID		54187	201163
HPRD ID		07285	06278
Ensembl ID		ENSG00000095380	ENSG00000154803
Uniprot IDs		Q9NR45	A0A0S2Z5Y7 Q8NFG4
PDB IDs		1WVO	3V42 6NZD 6ULG
Enriched GO Terms of Interacting Partners?
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