SEPTIN4 and AREL1

Data Source:
BioGRID (enzymatic study)

		SEPTIN4	AREL1
Description		septin 4	apoptosis resistant E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Septin Complex Cell Division Site Sperm Annulus	Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Spermatogenesis Regulation Of Exocytosis Cell Differentiation Positive Regulation Of Protein Ubiquitination Cellular Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cytoskeleton-dependent Cytokinesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			General factor of neuroticism ( 30867560) Mood instability ( 29187730)
Interacting Genes		9 interacting genes: AREL1 BCL2 PRKN SEPTIN5 SEPTIN8 SNCA SNCAIP SNCB XIAP	10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		5414	9870
HPRD ID		04738	13794
Ensembl ID		ENSG00000108387	ENSG00000119682
Uniprot IDs		O43236	O15033
PDB IDs			6JX5
Enriched GO Terms of Interacting Partners?
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