SEPTIN4 and SNCAIP

Data Source:
HPRD (in vivo)

		SEPTIN4	SNCAIP
Description		septin 4	synuclein alpha interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Septin Complex Cell Division Site Sperm Annulus	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body
	Molecular Function	Magnesium Ion Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Apoptotic Process Spermatogenesis Regulation Of Exocytosis Cell Differentiation Positive Regulation Of Protein Ubiquitination Cellular Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cytoskeleton-dependent Cytokinesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Death Dopamine Metabolic Process Cellular Protein Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly
Pathways			Amyloid fiber formation
Drugs
Diseases
GWAS			Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649) Delirium ( 29631748) Depressive symptoms x independent stressful life events interaction (2df test) ( 30718454) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mood disorder and prion disease ( 25897833) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539)
Interacting Genes		9 interacting genes: AREL1 BCL2 PRKN SEPTIN5 SEPTIN8 SNCA SNCAIP SNCB XIAP	19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB
Entrez ID		5414	9627
HPRD ID		04738	04804
Ensembl ID		ENSG00000108387	ENSG00000064692
Uniprot IDs		O43236	B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5
PDB IDs			2KES
Enriched GO Terms of Interacting Partners?
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