NUP54 and TACC3

Data Source:
BioGRID (two hybrid)

		NUP54	TACC3
Description		nucleoporin 54	transforming acidic coiled-coil containing protein 3
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GO Annotations	Cellular Component	Nuclear Envelope Nuclear Membrane Host Cell Nuclear Pore Central Transport Channel	Spindle Pole Cytoplasm Cytosol Centriolar Satellite Intracellular Membrane-bounded Organelle Mitotic Spindle
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Targeting NLS-bearing Protein Import Into Nucleus Nuclear Pore Organization Viral Process Protein Sumoylation Viral Transcription Protein Localization To Nuclear Inner Membrane Regulation Of Protein Import Into Nucleus Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Cell Population Proliferation Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation	NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS		Hippocampal volume ( 29274321)	Bladder cancer ( 24163127 20972438) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)
Interacting Genes		46 interacting genes: AGR2 AP1B1 AP2B1 APC BPIFA1 C14orf119 C1orf109 C21orf91 CCDC85B CCHCR1 CDC23 CENPH DCTN3 DGCR6 EFHC1 EIF3F EXOC1 EXOC8 HAUS1 HAUS8 HGS HOMER1 IFT20 KPNA1 KPNB1 KRT15 KRT27 KRT33B NFKBID NR3C1 NUP62 NUTF2 OIP5 PKNOX2 SMYD3 SOHLH1 SPG21 SSR1 TACC3 TCHP TEKT1 TEX12 TPM3 TRIM54 VPS37C ZWINT	29 interacting genes: AKAP9 ARHGDIG ARNT ARNT2 ASPSCR1 AURKA BEX2 BEX3 C2CD6 CCHCR1 CDC20B CIB3 CLIP4 EIF3C GDF15 IQCD KAT2A KIZ KLC1 KLHL38 NDEL1 NOD2 NUP54 RNF20 SNX20 SPATA18 TBC1D22B TTF2 VPS37C
Entrez ID		53371	10460
HPRD ID		06352	05601
Ensembl ID		ENSG00000138750	ENSG00000013810
Uniprot IDs		Q7Z3B4	Q9Y6A5
PDB IDs		4JNU 4JNV 4JO7 4JO9 5IJN 5IJO	5LXN 5LXO 5ODS 5ODT
Enriched GO Terms of Interacting Partners?
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