TACC3 and GDF15

Data Source:
BioGRID (two hybrid)

		TACC3	GDF15
Description		transforming acidic coiled-coil containing protein 3	growth differentiation factor 15
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Cytosol Centriolar Satellite Intracellular Membrane-bounded Organelle Mitotic Spindle	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity BMP Receptor Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Cell Population Proliferation Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways		NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS		Bladder cancer ( 24163127 20972438) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)	Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		29 interacting genes: AKAP9 ARHGDIG ARNT ARNT2 ASPSCR1 AURKA BEX2 BEX3 C2CD6 CCHCR1 CDC20B CIB3 CLIP4 EIF3C GDF15 IQCD KAT2A KIZ KLC1 KLHL38 NDEL1 NOD2 NUP54 RNF20 SNX20 SPATA18 TBC1D22B TTF2 VPS37C	7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3
Entrez ID		10460	9518
HPRD ID		05601	05608
Ensembl ID		ENSG00000013810	ENSG00000130513
Uniprot IDs		Q9Y6A5	Q99988
PDB IDs		5LXN 5LXO 5ODS 5ODT	5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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