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PKP2 and DSG2
Data Source:
HPRD
(two hybrid, in vivo)
PKP2
DSG2
Description
plakophilin 2
desmoglein 2
Image
GO Annotations
Cellular Component
Cornified Envelope
Nucleus
Nucleoplasm
Cytoplasm
Intermediate Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Intercalated Disc
Integral Component Of Membrane
Cell Junction
Desmosome
Messenger Ribonucleoprotein Complex
Cornified Envelope
Plasma Membrane
Cell-cell Junction
Cell Surface
Intercalated Disc
Integral Component Of Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Cell Junction
Desmosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Protein Kinase C Binding
Protein Binding
Sodium Channel Regulator Activity
Intermediate Filament Binding
Ion Channel Binding
Alpha-catenin Binding
Cadherin Binding
Molecular Adaptor Activity
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Calcium Ion Binding
Cell Adhesion Molecule Binding
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Biological Process
Desmosome Assembly
Desmosome Organization
Cell-cell Junction Assembly
Heart Development
Positive Regulation Of Sodium Ion Transport
Keratinization
Intermediate Filament Bundle Assembly
Maintenance Of Animal Organ Identity
Ventricular Cardiac Muscle Tissue Morphogenesis
Cornification
Protein Localization To Plasma Membrane
Cardiac Muscle Cell Action Potential Involved In Contraction
Ventricular Cardiac Muscle Cell Action Potential
Cell-cell Signaling Involved In Cardiac Conduction
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Desmosome Organization
Purkinje Myocyte Development
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Keratinization
Response To Progesterone
Maternal Process Involved In Female Pregnancy
Cornification
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways
Keratinization
Formation of the cornified envelope
Apoptotic cleavage of cell adhesion proteins
Keratinization
Formation of the cornified envelope
Drugs
Diseases
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS
Atrial fibrillation (
30061737
29892015
)
Blood protein levels (
30072576
)
Body mass index (change over time) in lung cancer (
28044437
)
Methadone dose in opioid dependence (
28115739
)
Obesity-related traits (
23251661
)
Parkinson's disease (
32201043
27182965
)
Periodontal disease related phenotype (PCT5) (
26962152
)
Prevalent atrial fibrillation (
28416818
)
Blood protein levels (
30072576
29875488
)
Interacting Genes
40 interacting genes:
ACTN3
AKAP9
CARD9
CASK
CCDC120
CCDC125
CCHCR1
CTNNB1
DMRTB1
DSC1
DSC2
DSG1
DSG2
DSP
FHL3
GOLGA2
GRIPAP1
GTF2IRD1
HOOK2
HSPB2
JUP
KLC4
KRT18
KRT31
KRT5
MAGOHB
MARK3
MTUS2
NCKIPSD
NDEL1
PIBF1
PLEKHG4
POLR3A
RABEP1
RBM5
ROPN1
SMAD9
SPTA1
TEKT4
YWHAG
5 interacting genes:
DSC1
DSC2
JUP
PKP2
PKP3
Entrez ID
5318
1829
HPRD ID
04177
00516
Ensembl ID
ENSG00000057294
ENSG00000046604
Uniprot IDs
Q99959
Q14126
PDB IDs
3TT9
2YQG
5ERD
5J5J
6QNT
6QNU
6SIT
7AGF
7AGG
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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