DSG2 and DSC1

Data Source:
HPRD (in vivo, in vitro)

		DSG2	DSC1
Description		desmoglein 2	desmocollin 1
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GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Cell-cell Junction Cell Surface Intercalated Disc Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Desmosome Intracellular Membrane-bounded Organelle Extracellular Exosome	Cornified Envelope Plasma Membrane Cell-cell Junction Gap Junction Membrane Integral Component Of Membrane Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Calcium Ion Binding Protein Binding
	Biological Process	Desmosome Organization Purkinje Myocyte Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Response To Progesterone Maternal Process Involved In Female Pregnancy Cornification Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Neutrophil Degranulation Cornification Cell-cell Adhesion
Pathways		Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope	Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Blood protein levels ( 30072576 29875488)	Multiple sclerosis ( 23412934)
Interacting Genes		5 interacting genes: DSC1 DSC2 JUP PKP2 PKP3	8 interacting genes: DSG1 DSG2 DSP JUP PKP1 PKP2 PKP3 UCHL5
Entrez ID		1829	1823
HPRD ID		00516	00511
Ensembl ID		ENSG00000046604	ENSG00000134765
Uniprot IDs		Q14126	Q08554 Q9HB00
PDB IDs		2YQG 5ERD 5J5J 6QNT 6QNU 6SIT 7AGF 7AGG	5IRY
Enriched GO Terms of Interacting Partners?
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