PKP1 and DSC1

Data Source:
HPRD (two hybrid)

		PKP1	DSC1
Description		plakophilin 1	desmocollin 1
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GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Adherens Junction Desmosome Ficolin-1-rich Granule Membrane Messenger Ribonucleoprotein Complex	Cornified Envelope Plasma Membrane Cell-cell Junction Gap Junction Membrane Integral Component Of Membrane Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Skin Epidermis Cadherin Binding	Calcium Ion Binding Protein Binding
	Biological Process	Cell-cell Junction Assembly Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Keratinization Neutrophil Degranulation Intermediate Filament Bundle Assembly Cornification Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Neutrophil Degranulation Cornification Cell-cell Adhesion
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope	Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases		Ectodermal dysplasia/skin fragility syndrome
GWAS		Panic disorder ( 19165232) Youthful appearance (self-reported) ( 32339537)	Multiple sclerosis ( 23412934)
Interacting Genes		16 interacting genes: BICDL2 CARD10 CEP76 DSC1 DSG1 DSP GOLGA2 GTF2IRD1 HOOK2 HSF2BP KRT14 KRT8 NFKBID TNS2 UCHL5 VIM	8 interacting genes: DSG1 DSG2 DSP JUP PKP1 PKP2 PKP3 UCHL5
Entrez ID		5317	1823
HPRD ID		03579	00511
Ensembl ID		ENSG00000081277	ENSG00000134765
Uniprot IDs		A0A024R952 Q13835	Q08554 Q9HB00
PDB IDs		1XM9	5IRY
Enriched GO Terms of Interacting Partners?
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