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PITX1 and SERPINE1
Data Source:
BioGRID
(two hybrid)
PITX1
SERPINE1
Description
paired like homeodomain 1
serpin family E member 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Transcription Regulator Complex
Cytoplasm
Extracellular Region
Extracellular Space
Plasma Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Protease Binding
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Biological Process
Skeletal System Development
Regulation Of Transcription By RNA Polymerase II
Anatomical Structure Morphogenesis
Branchiomeric Skeletal Muscle Development
Pituitary Gland Development
Embryonic Hindlimb Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Myoblast Fate Commitment
Cartilage Development
Angiogenesis
Platelet Degranulation
Circadian Rhythm
Regulation Of Signaling Receptor Activity
Negative Regulation Of Plasminogen Activation
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Blood Coagulation
Negative Regulation Of Blood Coagulation
Extracellular Matrix Organization
Negative Regulation Of Cell Migration
Positive Regulation Of Interleukin-8 Production
Negative Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Leukotriene Production Involved In Inflammatory Response
Fibrinolysis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Inflammatory Response
Defense Response To Gram-negative Bacterium
Negative Regulation Of Fibrinolysis
Negative Regulation Of Vascular Wound Healing
Negative Regulation Of Wound Healing
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotaxis
Replicative Senescence
Dentinogenesis
Positive Regulation Of Odontoblast Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Smooth Muscle Cell-matrix Adhesion
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Platelet degranulation
BMAL1:CLOCK,NPAS2 activates circadian gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
ECM proteoglycans
Dissolution of Fibrin Clot
Drugs
Alteplase
Urokinase
Reteplase
Anistreplase
Tenecteplase
Drotrecogin alfa
Troglitazone
Fibrinolysin
Copper
Diseases
Congenital clubfoot; Congenital talipes equinovarus
Inherited thrombophilia
GWAS
Atrial fibrillation (
29237688
)
Bulimia nervosa (
23568457
)
Colorectal cancer (
30529582
24836286
23263487
)
Colorectal cancer or advanced adenoma (
30510241
)
Height (
20881960
25429064
23563607
31562340
18391951
)
Immune response to anthrax vaccine (
22658931
)
Testicular germ cell tumor (
28604732
23666240
)
Blood protein levels (
30072576
)
Nonunion in individuals with fractures (
30680360
)
Plasma plasminogen activator levels (
24578379
)
Plasminogen activator inhibitor type 1 levels (PAI-1) (
22990020
)
Interacting Genes
98 interacting genes:
ABHD11
AKAP8L
ALG13
ANKRD10
ARID5A
ATN1
BPIFA1
C10orf55
C11orf1
C19orf54
C1orf94
C9orf57
CDX4
CEACAM6
CYSRT1
DCTN3
DVL3
DZIP3
EFEMP2
EGR1
FAM168A
FAM168B
FOXO1
GATA1
GOLGA2
HGS
HOXA1
HSF4
HYI
IGFL2
IPO13
KLHL26
KRT34
KRT83
KRTAP13-1
KRTAP13-2
KRTAP19-5
KRTAP19-7
KRTAP26-1
KRTAP3-3
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
LASP1
LZTS2
MAGED1
METTL27
MGAT5B
MSX2
MYH7B
MYOZ3
NEUROD1
NHLRC4
NID2
NR5A1
PFDN5
PLA2G10
PLEKHB2
PLSCR1
PLSCR3
POU1F1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMB11
PTK6
RBPMS
RFX6
RHOXF2
RNF31
ROR2
SERGEF
SERPINE1
SIK1B
SLC15A2
SMARCA2
SPAG8
STH
TBX19
TBX22
TEKT5
TFAP2D
TLE5
TP53BP1
TRAF1
TRAPPC2
TRIM23
TSC1
UFSP1
UPF2
VGLL3
YPEL3
ZBTB32
ZNF34
25 interacting genes:
ACTN4
ELANE
F2
HSD17B11
IGFBP5
KLK2
KRT18
LMNA
LRP1
LRP1B
LRP2
MMP3
ORM1
PITX1
PLAT
PLAU
PLG
SGTA
SGTB
TLX3
TMEM237
UBQLN1
UBQLN2
UBQLN4
VTN
Entrez ID
5307
5054
HPRD ID
03688
01418
Ensembl ID
ENSG00000069011
ENSG00000106366
Uniprot IDs
P78337
X5D9A5
A0A024QYT5
P05121
PDB IDs
1A7C
1B3K
1C5G
1DB2
1DVM
1DVN
1LJ5
1OC0
3CVM
3EOX
3PB1
3Q02
3Q03
3R4L
3UT3
4AQH
4G8O
4G8R
4IC0
5BRR
5ZLZ
6GWN
6GWP
6GWQ
6I8S
6ZRV
9PAI
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Difference)
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Tagcloud (Intersection)
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