ENPP1 and USP2

Data Source:
BioGRID (enzymatic study)

		ENPP1	USP2
Description		ectonucleotide pyrophosphatase/phosphodiesterase 1	ubiquitin specific peptidase 2
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GO Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane	Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleic Acid Binding Exonuclease Activity Phosphodiesterase I Activity Nucleotide Diphosphatase Activity Scavenger Receptor Activity Insulin Receptor Binding Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Polysaccharide Binding NADH Pyrophosphatase Activity DTTP Diphosphatase Activity Protein Homodimerization Activity Nucleoside-triphosphate Diphosphatase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding Cyclic-GMP-AMP Hydrolase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Riboflavin Metabolic Process Phosphate-containing Compound Metabolic Process Endocytosis Immune Response Nucleoside Triphosphate Catabolic Process Negative Regulation Of Cell Growth Melanocyte Differentiation Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Inorganic Diphosphate Transport Cellular Phosphate Ion Homeostasis Sequestering Of Triglyceride Biomineral Tissue Development Negative Regulation Of Protein Autophosphorylation Cellular Response To Insulin Stimulus Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Glycogen Biosynthetic Process ATP Metabolic Process Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Negative Regulation Of Hh Target Transcription Factor Activity	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cell Cycle Muscle Organ Development Protein Deubiquitination Protein Phosphopantetheinylation Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Protein Stabilization
Pathways		Vitamin B2 (riboflavin) metabolism Vitamin B5 (pantothenate) metabolism	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation
Drugs		Taribavirin Polyethylene glycol 400
Diseases		Ossification of the posterior longitudinal ligament of spine (OPLL) Type II diabetes mellitus Generalized arterial calcification of infancy
GWAS		Height ( 28552196) Obesity-related traits ( 23251661)	Refractive error ( 32231278) Serum uric acid levels ( 30993211) Urate levels ( 31985003 31578528 23263486)
Interacting Genes		2 interacting genes: INSR USP2	163 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP ASPG ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BHLHB9 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CCND1 CEP63 CEP70 CRACR2A CRACR2B CRY1 CTNNB1 DDI1 DEPDC5 DISC1 DTX3 DUSP21 DYDC1 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GRB7 GRIPAP1 H2AC20 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PCNA PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF166 RUNDC3A S100A10 SH2B2 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1
Entrez ID		5167	9099
HPRD ID		01415	05287
Ensembl ID		ENSG00000197594	ENSG00000036672
Uniprot IDs		P22413	O75604
PDB IDs		2YS0 6WET 6WEU 6WEV 6WEW 6WFJ	2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF
Enriched GO Terms of Interacting Partners?
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