ENPP1

Description		ectonucleotide pyrophosphatase/phosphodiesterase 1
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GO Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Nucleic Acid Binding Exonuclease Activity Phosphodiesterase I Activity Nucleotide Diphosphatase Activity Scavenger Receptor Activity Insulin Receptor Binding Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Polysaccharide Binding NADH Pyrophosphatase Activity DTTP Diphosphatase Activity Protein Homodimerization Activity Nucleoside-triphosphate Diphosphatase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding Cyclic-GMP-AMP Hydrolase Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Riboflavin Metabolic Process Phosphate-containing Compound Metabolic Process Endocytosis Immune Response Nucleoside Triphosphate Catabolic Process Negative Regulation Of Cell Growth Melanocyte Differentiation Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Inorganic Diphosphate Transport Cellular Phosphate Ion Homeostasis Sequestering Of Triglyceride Biomineral Tissue Development Negative Regulation Of Protein Autophosphorylation Cellular Response To Insulin Stimulus Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Glycogen Biosynthetic Process ATP Metabolic Process Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Negative Regulation Of Hh Target Transcription Factor Activity
Pathways		Vitamin B2 (riboflavin) metabolism Vitamin B5 (pantothenate) metabolism
Drugs		Taribavirin Polyethylene glycol 400
Diseases		Ossification of the posterior longitudinal ligament of spine (OPLL) Type II diabetes mellitus Generalized arterial calcification of infancy
GWAS		Height ( 28552196) Obesity-related traits ( 23251661)
Interacting Genes		2 interacting genes: INSR USP2
Entrez ID		5167
HPRD ID		01415
Ensembl ID		ENSG00000197594
Uniprot IDs		P22413
PDB IDs		2YS0 6WET 6WEU 6WEV 6WEW 6WFJ
Enriched GO Terms of Interacting Partners?
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