GET4 and PRKCSH

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GET4	PRKCSH
Description		guided entry of tail-anchored proteins factor 4	protein kinase C substrate 80K-H
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol BAT3 Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Glucosidase II Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Chaperone Binding	Protein Kinase C Binding Calcium Ion Binding Protein Binding Ion Channel Binding Phosphoprotein Binding
	Biological Process	Protein Insertion Into ER Membrane Cytoplasmic Sequestering Of Protein Tail-anchored Membrane Protein Insertion Into ER Membrane Maintenance Of Unfolded Protein Involved In ERAD Pathway	Liver Development Protein Folding N-glycan Processing Intracellular Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Post-translational protein phosphorylation Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein
Drugs
Diseases			Polycystic liver disease
GWAS		PR interval ( 32439900)	Presence of antiphospholipid antibodies ( 27098658) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		29 interacting genes: AKT1 ATP5PD BAG6 C1orf109 CAPNS1 CDKN1A CEP126 DUSP21 EEF1G ENKD1 FBN1 FLYWCH2 GET3 GIT2 KAT5 KIFC2 KRTAP9-3 NUP85 PLK1 PRKAB2 PRKCSH PTMS SDCBP SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2	10 interacting genes: ARL4D CANX ESR1 GANAB GBA3 GET4 PTPRC RGS2 RPS6 VDR
Entrez ID		51608	5589
HPRD ID		12909	03518
Ensembl ID		ENSG00000239857	ENSG00000130175
Uniprot IDs		Q7L5D6	B4DJQ5 K7ELL7 P14314
PDB IDs		6AU8
Enriched GO Terms of Interacting Partners?
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