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IL23A and IL12RB1
Data Source:
HPRD
(in vivo)
IL23A
IL12RB1
Description
interleukin 23 subunit alpha
interleukin 12 receptor subunit beta 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Endoplasmic Reticulum Lumen
Interleukin-23 Complex
Plasma Membrane
External Side Of Plasma Membrane
Interleukin-12 Receptor Complex
Receptor Complex
Interleukin-23 Receptor Complex
Molecular Function
Cytokine Activity
Protein Binding
Interleukin-23 Receptor Binding
Cytokine Receptor Activity
Interleukin-12 Receptor Binding
Interleukin-12 Receptor Activity
Cytokine Binding
Interleukin-23 Binding
Interleukin-23 Receptor Activity
Biological Process
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Defense Response To Virus By Host
Positive Regulation Of T-helper 1 Type Immune Response
Inflammatory Response
Positive Regulation Of Activation Of Janus Kinase Activity
Cytokine-mediated Signaling Pathway
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Activation
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Tissue Remodeling
Interleukin-23-mediated Signaling Pathway
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Memory T Cell Differentiation
Innate Immune Response
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Tissue Remodeling
Positive Regulation Of Inflammatory Response
Defense Response To Gram-negative Bacterium
Positive Regulation Of NK T Cell Activation
Positive Regulation Of NK T Cell Proliferation
Defense Response To Virus
Positive Regulation Of Neutrophil Chemotaxis
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of T-helper 17 Cell Lineage Commitment
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Defense Response To Virus By Host
Positive Regulation Of T-helper 1 Type Immune Response
Signal Transduction
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interferon-gamma Production
Interleukin-12-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Memory T Cell Differentiation
Cellular Response To Interferon-gamma
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways
Interleukin-4 and Interleukin-13 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Drugs
Briakinumab
Ustekinumab
Guselkumab
Tildrakizumab
Risankizumab
Diseases
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS
Axial length (
24144296
)
Psoriasis (
25903422
20953190
25574825
23143594
19169254
)
Psoriasis vulgaris (
26626624
)
Psoriatic arthritis (
26626624
)
Refractive error (
32231278
)
Blood protein levels (
28240269
)
Mental health study participation (completed survey) (
31263887
)
Pulmonary function in asthmatics (
23541324
)
Systemic sclerosis (
31672989
30572963
)
Interacting Genes
3 interacting genes:
IL12RB1
IL23R
PEX19
6 interacting genes:
IL12B
IL12RB2
IL23A
IL23R
SNRPD3
STAT4
Entrez ID
51561
3594
HPRD ID
12026
03363
Ensembl ID
ENSG00000110944
ENSG00000096996
Uniprot IDs
Q9NPF7
P42701
PDB IDs
3D85
3D87
3DUH
3QWR
4GRW
5MJ3
5MJ4
5MXA
5MZV
5NJD
6UIB
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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