IL12RB1

Description		interleukin 12 receptor subunit beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Interleukin-12 Receptor Activity Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs
Diseases		IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Blood protein levels ( 28240269) Mental health study participation (completed survey) ( 31263887) Pulmonary function in asthmatics ( 23541324) Systemic sclerosis ( 31672989 30572963)
Novel Interacting Genes		1 novel interacting genes: BRD4
Interacting Genes		6 interacting genes: IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4
Entrez ID		3594
HPRD ID		03363
Ensembl ID		ENSG00000096996
Uniprot IDs		P42701
PDB IDs
Enriched GO Terms of Interacting Partners?
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