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SPG21 and VPS25
Data Source:
BioGRID
(two hybrid)
SPG21
VPS25
Description
SPG21 abhydrolase domain containing, maspardin
vacuolar protein sorting 25 homolog
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Apparatus
Cytosol
Endosome Membrane
Trans-Golgi Network Transport Vesicle
Intracellular Membrane-bounded Organelle
ESCRT II Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Extracellular Exosome
Molecular Function
Protein Binding
CD4 Receptor Binding
Structural Molecule Activity
Protein Binding
Protein Homodimerization Activity
Protein N-terminus Binding
Biological Process
Antigen Receptor-mediated Signaling Pathway
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Endosomal Transport
Macroautophagy
Multivesicular Body Assembly
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Pathways
Endosomal Sorting Complex Required For Transport (ESCRT)
HCMV Late Events
Drugs
Diseases
Hereditary spastic paraplegia (SPG)
GWAS
Interacting Genes
164 interacting genes:
ACOT13
AGTR1
AGTRAP
AKIRIN2
APOC1
ARL6IP1
ARL8A
ARMC12
ARMC7
ATP5ME
ATPAF2
BORCS6
BSND
C10orf82
C9orf24
CCDC102B
CCDC153
CCDC33
CCHCR1
CD4
CDK2AP1
CDKN2B
CEP76
CEPT1
CFAP410
CIDEB
CLDN22
CMTM4
CMTM5
CMTM6
COG3
COG6
CPSF7
CRX
CRYAA
CRYAA2
CT55
CTIF
CTPS2
CUTC
DCTPP1
DTX2
DTX3L
EFHC2
EIF1B
EIF4H
EYA2
FAM114A1
FAM86C1P
FBXO44
FLACC1
GAD2
GAS8
GEMIN2
GEMIN4
GGA2
GOLGA2
GOLT1B
GRPEL1
GSK3A
HNRNPH1
HPRT1
HSD17B13
IKZF3
INCA1
IQCB1
KCTD9
KRT13
KRT15
KRT19
KRT31
LEPROTL1
LMNA
LMO1
LNX1
LSMEM2
MAB21L3
MID2
MPC2
MTMR9
MTUS2
MYG1
MYOG
N4BP3
NAB2
NDUFAF2
NIF3L1
NME4
NQO2
NR1D1
NRDE2
NUP54
PAX6
PBX4
PCBD2
PCNA
PDE5A
PEF1
PFDN5
PLP2
PNMA5
PPM1J
PRPS1
PRTFDC1
PSMB4
PTPA
RABAC1
RAD51C
REEP6
REL
ROPN1
RPRD1B
RPS19
RTL8B
RTN4
S100B
SATB1
SCAMP1
SEPTIN5
SFT2D1
SH3GL1
SLC35E3
SORBS3
SPRED1
SPRED2
SRGAP2B
SSBP4
SWSAP1
SYNGR1
SYNGR3
SYP
TCF12
TCF4
TEKT4
TFG
TFIP11
TLE5
TMEM208
TMEM239
TOX2
TPD52
TRAF1
TRAF2
TRIB3
TRIM14
TRIM23
TRIM50
TRIM54
TRIM9
TSGA10IP
TSNAXIP1
TTC23L
TXN
TXNL4B
UFSP1
USHBP1
VMAC
VPS25
YPEL3
ZBTB42
ZMYND12
ZNF263
ZNF581
ZNF629
21 interacting genes:
APIP
ASPG
B9D2
BEND5
BPIFA1
CHMP6
CRLF3
GPR35
LTB4R2
PICK1
REL
RHOXF2
SDCBP2
SEPTIN14
SNF8
SPG21
SPRY2
SYCE1
TADA2A
TRIM27
VPS36
Entrez ID
51324
84313
HPRD ID
10492
14396
Ensembl ID
ENSG00000090487
ENSG00000131475
Uniprot IDs
A0A024R5Y1
Q9NZD8
A0A024R1X3
Q9BRG1
PDB IDs
2ZME
3CUQ
3HTU
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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