VPS25 and CHMP6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro, in vivo)

		VPS25	CHMP6
Description		vacuolar protein sorting 25 homolog	charged multivesicular body protein 6
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GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Extracellular Exosome	ESCRT III Complex Multivesicular Body Cytosol Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity Protein N-terminus Binding	Protein Binding Protein-containing Complex Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Endosomal Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Vesicle Budding From Membrane Nucleus Organization Mitotic Metaphase Plate Congression Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Protein Catabolic Process Midbody Abscission Regulation Of Exosomal Secretion ESCRT III Complex Assembly
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS
Interacting Genes		21 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 VPS36	7 interacting genes: CHMP4A CHMP4B ELOF1 METTL9 SNF8 VPS25 VPS36
Entrez ID		84313	79643
HPRD ID		14396	08564
Ensembl ID		ENSG00000131475	ENSG00000176108
Uniprot IDs		A0A024R1X3 Q9BRG1	Q96FZ7
PDB IDs		2ZME 3CUQ 3HTU	2K3W 3HTU
Enriched GO Terms of Interacting Partners?
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