PHF21A and RCOR1

Data Source:
HPRD (in vitro)

		PHF21A	RCOR1
Description		PHD finger protein 21A	REST corepressor 1
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleoplasm DNA Repair Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex DNA Repair Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Metal Ion Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Enzyme Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Blood Coagulation	Regulation Of Transcription By RNA Polymerase II Blood Coagulation Viral Process Histone Deacetylation Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Histone H4 Deacetylation
Pathways		HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production	HDACs deacetylate histones Regulation of PTEN gene transcription Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Axial length ( 24144296) Height ( 29782485) Menarche (age at onset) ( 21102462 25231870) Refractive error ( 32231278) Triglyceride levels ( 32203549) Urate levels ( 31578528)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body mass index ( 26426971) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Platelet count ( 22139419 32888494 27863252) Plateletcrit ( 32888494 27863252)
Interacting Genes		18 interacting genes: BANP EXOSC8 FHL2 FHL3 H3C14 HDAC1 HDAC2 HMG20A HMG20B KDM1A KRT40 L3MBTL3 LPXN NUP62 RCOR1 SP3 TRAF1 ZYX	12 interacting genes: CTBP1 FOXK2 H3-4 HDAC2 KDM1A PHF21A REST SMARCE1 SNAI1 SUB1 SUMO2 ZMYM2
Entrez ID		51317	23186
HPRD ID		10516	09645
Ensembl ID		ENSG00000135365	ENSG00000089902
Uniprot IDs		Q96BD5	Q9UKL0
PDB IDs		2PUY 2YQL	2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC 4UXN 4XBF 5H6Q 5H6R 5L3B 5L3C 5L3D 5L3E 5L3F 5L3G 5LBQ 5LGN 5LGT 5LGU 5LHG 5LHH 5LHI 5X60 5YJB 6K3E 6KGK 6KGL 6KGM 6KGN 6S35 6TE1 6VYP 6W4K
Enriched GO Terms of Interacting Partners?
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