ABHD5 and COQ8A

Data Source:
BioGRID (two hybrid)

		ABHD5	COQ8A
Description		abhydrolase domain containing 5, lysophosphatidic acid acyltransferase	coenzyme Q8A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Lipid Droplet Cytosol Intracellular Membrane-bounded Organelle	Mitochondrion Integral Component Of Membrane Extrinsic Component Of Mitochondrial Inner Membrane
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Triglyceride Lipase Activity Protein Binding Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity	Protein Kinase Activity Protein Binding ATP Binding Kinase Activity ADP Binding
	Biological Process	Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Cell Differentiation Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis	Protein Phosphorylation Ubiquinone Biosynthetic Process Phosphorylation
Pathways		Triglyceride catabolism
Drugs			Fostamatinib
Diseases		Dorfman-Chanarin syndrome; Chanarin-Dorfman syndrome	Coenzyme Q10 deficiency Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		General risk tolerance (MTAG) ( 30643258) Inflammatory skin disease ( 25574825)
Interacting Genes		21 interacting genes: CERCAM COQ8A DGAT2L6 GAD2 GET1 GRIA4 MIEF1 PCNX2 PLIN1 PLIN2 PLIN3 PNPLA2 RBFA RNF24 RUSC1 SH3GLB1 SLC44A3 TMEM14B TMEM31 TPD52L2 ZCCHC12	26 interacting genes: ABHD5 AGTRAP CCDC34 CMTM4 CMTM5 CMTM6 COQ9 DESI2 DTX2 JOSD2 MAL2 MRM1 MTIF3 ORMDL3 PBX3 RABAC1 REEP6 RPRM SH3GLB1 SMPD2 STX10 TFIP11 TMCO2 TMEM159 TMEM239 TPD52L2
Entrez ID		51099	56997
HPRD ID		11986	07375
Ensembl ID		ENSG00000011198	ENSG00000163050
Uniprot IDs		A0A0S2Z5D6 Q8WTS1	Q8NI60
PDB IDs			4PED 5I35
Enriched GO Terms of Interacting Partners?
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