CRYL1 and ABCC6

Data Source:
BioGRID (two hybrid)

		CRYL1	ABCC6
Description		crystallin lambda 1	ATP binding cassette subfamily C member 6
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane
	Molecular Function	3-hydroxyacyl-CoA Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity L-gulonate 3-dehydrogenase Activity NAD+ Binding	Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ATPase Activity Inorganic Diphosphate Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity
	Biological Process	Fatty Acid Metabolic Process Glucuronate Catabolic Process To Xylulose 5-phosphate	Drug Transmembrane Transport Visual Perception ATP Transport Inorganic Diphosphate Transport Response To Drug Xenobiotic Transport Transmembrane Transport Leukotriene Transport Anion Transmembrane Transport
Pathways		Formation of xylulose-5-phosphate	ABC-family proteins mediated transport Defective ABCC6 causes PXE
Drugs			ATP
Diseases			Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Obesity-related traits ( 23251661)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Multiple myeloma (survival) ( 26198393) Red blood cell count ( 32888494)
Interacting Genes		1 interacting genes: ABCC6	5 interacting genes: A1BG AK2 CRYL1 FURIN NR4A1
Entrez ID		51084	368
HPRD ID		16762	04453
Ensembl ID		ENSG00000165475	ENSG00000091262
Uniprot IDs		Q9Y2S2 V9HWG2	O95255
PDB IDs		3F3S	6BZR 6BZS 6NLO 6P7F
Enriched GO Terms of Interacting Partners?
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