ABCC6 and CRYL1

Data Source:
BioGRID (two hybrid)

		ABCC6	CRYL1
Description		ATP binding cassette subfamily C member 6	crystallin lambda 1
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane	Cytosol Extracellular Exosome
	Molecular Function	Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ATPase Activity Inorganic Diphosphate Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity	3-hydroxyacyl-CoA Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity L-gulonate 3-dehydrogenase Activity NAD+ Binding
	Biological Process	Drug Transmembrane Transport Visual Perception ATP Transport Inorganic Diphosphate Transport Response To Drug Xenobiotic Transport Transmembrane Transport Leukotriene Transport Anion Transmembrane Transport	Fatty Acid Metabolic Process Glucuronate Catabolic Process To Xylulose 5-phosphate
Pathways		ABC-family proteins mediated transport Defective ABCC6 causes PXE	Formation of xylulose-5-phosphate
Drugs		ATP
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Multiple myeloma (survival) ( 26198393) Red blood cell count ( 32888494)	Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Obesity-related traits ( 23251661)
Interacting Genes		5 interacting genes: A1BG AK2 CRYL1 FURIN NR4A1	1 interacting genes: ABCC6
Entrez ID		368	51084
HPRD ID		04453	16762
Ensembl ID		ENSG00000091262	ENSG00000165475
Uniprot IDs		O95255	Q9Y2S2 V9HWG2
PDB IDs		6BZR 6BZS 6NLO 6P7F	3F3S
Enriched GO Terms of Interacting Partners?
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