EXOSC3 and ATP5F1D

Data Source:
BioGRID (two hybrid)

		EXOSC3	ATP5F1D
Description		exosome component 3	ATP synthase F1 subunit delta
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Sector F(1) Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Protein Binding ATP Binding ATPase Activity ADP Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing	Oxidative Phosphorylation ATP Biosynthetic Process Aerobic Respiration ATP Synthesis Coupled Proton Transport Mitochondrial Proton-transporting ATP Synthase Complex Assembly Cristae Formation Mitochondrial ATP Synthesis Coupled Proton Transport Response To Copper Ion
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs			Isoflurane Desflurane
Diseases
GWAS
Interacting Genes		9 interacting genes: APP ATP5F1D CDK5RAP1 EXOSC4 EXOSC5 EXOSC9 KHSRP MPHOSPH6 TSR2	10 interacting genes: ATP5F1E EXOSC3 KRTAP10-8 MDFI NBPF19 NOTCH2NLA SRSF11 TRIM55 TRIM63 TTN
Entrez ID		51010	513
HPRD ID		16220	04397
Ensembl ID		ENSG00000107371	ENSG00000099624
Uniprot IDs		Q9NQT5 Q9NYS3	P30049
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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