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EXOSC3
Description
exosome component 3
Image
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Molecular Function
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
DNA Deamination
Isotype Switching
Positive Regulation Of Isotype Switching
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Novel Interacting Genes
2 novel interacting genes:
PRDM1
PRDX1
Interacting Genes
9 interacting genes:
APP
ATP5F1D
CDK5RAP1
EXOSC4
EXOSC5
EXOSC9
KHSRP
MPHOSPH6
TSR2
Entrez ID
51010
HPRD ID
16220
Ensembl ID
ENSG00000107371
Uniprot IDs
Q9NQT5
Q9NYS3
PDB IDs
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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