PCBP2 and HNRNPL

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, two hybrid)

		PCBP2	HNRNPL
Description		poly(rC) binding protein 2	heterogeneous nuclear ribonucleoprotein L
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Postsynaptic Density Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Membrane Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding C-rich Single-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Intronic Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of Gene Expression RNA Metabolic Process MRNA Metabolic Process Negative Regulation Of Type I Interferon Production Viral RNA Genome Replication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Defense Response To Virus Regulation Of RNA Metabolic Process Defense Response To Virus IRES-dependent Viral Translational Initiation	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing RNA Metabolic Process Regulation Of RNA Splicing
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Negative regulators of DDX58/IFIH1 signaling	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs			Copper
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anti-saccade response ( 29064472) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)
Interacting Genes		28 interacting genes: BARD1 CASK CNBP FLNA FTH1 HMGA1 HMGA2 HNRNPD HNRNPK HNRNPL LINC01554 NKAP PABPC1 PAXIP1 PCBP1 PRPF40A PTBP1 QKI SF3B2 SLU7 SNRPA SRSF3 SRSF7 UBC WDR77 WDR83 YBX1 YBX3	89 interacting genes: APEX1 CSE1L CSNK2A1 FGFR3 H3-4 HMG20B HMGA1 HNRNPA2B1 HNRNPK IL7R ITCH MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 PCBP2 PJA1 PTBP1 SUMO2 SUMO4
Entrez ID		5094	3191
HPRD ID		03129	04360
Ensembl ID		ENSG00000197111	ENSG00000104824
Uniprot IDs		A0A384N6B9 Q15366	P14866 Q6NTA2
PDB IDs		2AXY 2JZX 2P2R 2PQU 2PY9	3R27 3TO8
Enriched GO Terms of Interacting Partners?
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