PARD6A and PTPN21

Data Source:
BioGRID (two hybrid)

		PARD6A	PTPN21
Description		par-6 family cell polarity regulator alpha	protein tyrosine phosphatase non-receptor type 21
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Centriolar Satellite	Cytoplasm Cytoskeleton
	Molecular Function	Protein Kinase C Binding Protein Binding Transcription Factor Binding GTP-dependent Protein Binding Small GTPase Binding	Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cellular Localization Bicellular Tight Junction Assembly Positive Regulation Of Protein Localization To Centrosome	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Prudent dietary pattern ( 28644415)
Interacting Genes		26 interacting genes: APP CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ	27 interacting genes: AKAP1 BAG3 BMX CATSPER1 CWC22 ERBB4 FAM214B FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 UBASH3B VPS26C YAP1 ZNF497
Entrez ID		50855	11099
HPRD ID		06316	04468
Ensembl ID		ENSG00000102981	ENSG00000070778
Uniprot IDs		Q9NPB6	Q16825
PDB IDs		1WMH
Enriched GO Terms of Interacting Partners?
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