PARD6A and CDH5

Data Source:
HPRD (in vitro, in vivo)

		PARD6A	CDH5
Description		par-6 family cell polarity regulator alpha	cadherin 5
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Centriolar Satellite	Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Catenin Complex Cell Junction Nuclear Membrane
	Molecular Function	Protein Kinase C Binding Protein Binding Transcription Factor Binding GTP-dependent Protein Binding Small GTPase Binding	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Vascular Endothelial Growth Factor Receptor 2 Binding Ion Channel Binding Cadherin Binding Fibrinogen Binding BMP Receptor Binding Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cellular Localization Bicellular Tight Junction Assembly Positive Regulation Of Protein Localization To Centrosome	Cell Morphogenesis Regulation Of Protein Phosphorylation Vasculature Development Blood Vessel Maturation Cellular Calcium Ion Homeostasis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Positive Regulation Of Protein Dephosphorylation Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins	Adherens junctions interactions VEGFR2 mediated vascular permeability
Drugs			Lenalidomide FX06
Diseases
GWAS		Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Body size at age 10 ( 32376654) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)
Interacting Genes		26 interacting genes: APP CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ	21 interacting genes: CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM
Entrez ID		50855	1003
HPRD ID		06316	03075
Ensembl ID		ENSG00000102981	ENSG00000179776
Uniprot IDs		Q9NPB6	P33151 Q59EA3
PDB IDs		1WMH
Enriched GO Terms of Interacting Partners?
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