ORC2 and CDC45

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, in vitro)

		ORC2	CDC45
Description		origin recognition complex subunit 2	cell division cycle 45
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body
	Molecular Function	DNA Replication Origin Binding Protein Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS		Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)	Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		28 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RIPPLY3 RPA1 RPA2 XRCC5	25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1
Entrez ID		4999	8318
HPRD ID		03112	09145
Ensembl ID		ENSG00000115942	ENSG00000093009
Uniprot IDs		A0A024R411 Q13416	O75419
PDB IDs		5C8H 5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS	5DGO 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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