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ORC2 and RIPPLY3
Data Source:
BioGRID
(two hybrid)
ORC2
RIPPLY3
Description
origin recognition complex subunit 2
ripply transcriptional repressor 3
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Heterochromatin
Origin Recognition Complex
Condensed Chromosome Inner Kinetochore
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Centrosome
Membrane
Nucleus
Molecular Function
DNA Replication Origin Binding
Protein Binding
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
DNA Replication
DNA Replication Initiation
Negative Regulation Of Transcription By RNA Polymerase II
Heart Development
Biological_process
Negative Regulation Of Cell Population Proliferation
Embryonic Pattern Specification
Pharyngeal System Development
Pathways
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Drugs
Diseases
GWAS
Plasma parathyroid hormone levels (
30134803
)
Triptolide cytotoxicity (
26121980
)
Interacting Genes
28 interacting genes:
CDC45
CDC5L
CDC6
CDK2
CDT1
CTNNA3
DBF4
EP300
H3-4
H4-16
KAT7
MCM10
MCM2
MCM3
MCM4
MCM5
MCM6
MCM7
ORC1
ORC3
ORC4
ORC5
ORC6
RAD18
RIPPLY3
RPA1
RPA2
XRCC5
7 interacting genes:
CEP76
INCA1
MCRS1
ORC2
PSMB1
TIFA
TRAF2
Entrez ID
4999
53820
HPRD ID
03112
10923
Ensembl ID
ENSG00000115942
ENSG00000183145
Uniprot IDs
A0A024R411
Q13416
P57055
PDB IDs
5C8H
5UJ8
5UJM
7JPO
7JPP
7JPQ
7JPR
7JPS
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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