NPPA and NPR1

Data Source:
HPRD (in vivo)

		NPPA	NPR1
Description		natriuretic peptide A	natriuretic peptide receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Protein-containing Complex Cell Projection Perikaryon Collagen-containing Extracellular Matrix	Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Hormone Receptor Binding Neuropeptide Receptor Binding	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Protein Kinase Binding Hormone Binding
	Biological Process	Negative Regulation Of Systemic Arterial Blood Pressure Aortic Valve Morphogenesis CGMP Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate CGMP-mediated Signaling Response To Muscle Stretch Vasodilation Negative Regulation Of JUN Kinase Activity Cellular Protein Metabolic Process Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Cardiac Conduction	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Positive Regulation Of CGMP-mediated Signaling Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance Regulation Of Cardiac Conduction
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation	Physiological factors
Drugs			Nitroprusside Nitroglycerin Isosorbide dinitrate Amyl Nitrite Erythrityl tetranitrate Nesiritide Ularitide
Diseases		Atrial fibrillation
GWAS		Atrial fibrillation ( 19597492) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Midregional pro atrial natriuretic peptide levels ( 29237677) Psoriasis ( 25854761) Pulse pressure ( 30578418) Systolic blood pressure ( 19430483 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)	Mean arterial pressure ( 27618448) Systolic blood pressure ( 27618448)
Interacting Genes		14 interacting genes: EPB41 ESR1 HNF4A HSF2BP MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN2 UBQLN4	7 interacting genes: ATF7IP MTDH NPPA NPPB NPPC PRKG1 UBE2D2
Entrez ID		4878	4881
HPRD ID		00164	00165
Ensembl ID		ENSG00000175206	ENSG00000169418
Uniprot IDs		P01160	A0A140VJE6 P16066
PDB IDs		1ANP 1YK0 3N57
Enriched GO Terms of Interacting Partners?
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