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NEDD4 and CASP1
Data Source:
HPRD
(in vitro, in vivo)
NEDD4
CASP1
Description
NEDD4 E3 ubiquitin protein ligase
caspase 1
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Chromatin
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Cortex
Apicolateral Plasma Membrane
Protein-containing Complex
Dendritic Spine
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Extracellular Region
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Protein-containing Complex
IPAF Inflammasome Complex
NLRP1 Inflammasome Complex
NLRP3 Inflammasome Complex
AIM2 Inflammasome Complex
Protease Inhibitor Complex
Molecular Function
Protein Binding
Sodium Channel Inhibitor Activity
Enzyme Binding
Protein Domain Specific Binding
Beta-2 Adrenergic Receptor Binding
Ubiquitin Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase Binding
Proline-rich Region Binding
Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Kinase Binding
Identical Protein Binding
CARD Domain Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Lysosome
Lysosomal Transport
Neuromuscular Junction Development
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Macroautophagy
Protein Ubiquitination
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Receptor Internalization
Receptor Catabolic Process
Cellular Response To UV
Regulation Of Ion Transmembrane Transport
Regulation Of Membrane Potential
Glucocorticoid Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Development Involved In Symbiotic Interaction
Positive Regulation Of Protein Catabolic Process
Viral Budding
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Progesterone Receptor Signaling Pathway
Response To Calcium Ion
Protein K63-linked Ubiquitination
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Response To Hypoxia
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Regulation Of Autophagy
Protein Autoprocessing
Cytokine-mediated Signaling Pathway
Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Alpha Production
Positive Regulation Of Interleukin-1 Beta Production
Response To ATP
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Inflammatory Response
Mitochondrial Depolarization
Membrane Hyperpolarization
Pyroptosis
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Organic Substance
Cellular Response To Cytokine Stimulus
Cellular Response To Interferon-gamma
Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Programmed Necrotic Cell Death
Signaling Receptor Ligand Precursor Processing
Toxin Transport
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways
ISG15 antiviral mechanism
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
NOD1/2 Signaling Pathway
Interleukin-1 processing
TP53 Regulates Transcription of Caspase Activators and Caspases
The NLRP3 inflammasome
The AIM2 inflammasome
The IPAF inflammasome
Interleukin-37 signaling
Purinergic signaling in leishmaniasis infection
Drugs
Acetylsalicylic acid
Minocycline
Pralnacasan
LAX-101
Emricasan
VX-765
1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE
Z-Val-Ala-Asp fluoromethyl ketone
3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS
Brain connectivity (
23471985
)
Chronic lymphocytic leukemia (
28165464
24292274
)
Dupuytren's disease (
28886342
)
Hip circumference adjusted for BMI (
28552196
)
Intraocular pressure (
29617998
)
Joint mobility (Beighton score) (
27182965
)
Keloid (
20711176
)
Refractive error (
32231278
)
Stroke (
29531354
)
Hip circumference adjusted for BMI (
28552196
)
Interacting Genes
238 interacting genes:
ABCB1
ABL1
ABL2
ADRB2
AKT3
AMOT
AMOTL1
AMPD2
ANKRD13D
ANXA13
AP1G2
ARID1A
ASPSCR1
AURKC
BAIAP2
BMPR1A
BRCA2
CAD
CALCOCO1
CAMK1D
CAMK4
CAMKK2
CASP1
CASP3
CASP6
CASP7
CBLB
CCNH
CDC25C
CDK5
CDK5R1
CLIC2
CLK3
CPSF1
CPSF6
CUEDC1
DAZAP2
DCUN1D1
DDX3X
DDX54
DHX30
DIAPH1
DVL1
DYRK4
EBAG9
EGFR
EPHA5
EPRS1
EPS15
ERBB3
ERBB4
ERMN
ERRFI1
FES
FGF12
FGF21
FGFR1
FGFR2
FKBP3
FLT1
FLT4
FYN
GABARAP
GABARAPL1
GABARAPL2
GBA
GFUS
GRB10
GRIN2A
GRK4
GRK7
H3-3A
HGS
HMCES
HNRNPK
HNRNPL
HNRNPU
HNRNPUL1
IFITM3
IGF1R
IRS1
IRS2
JHY
JUN
KCNAB1
KCNAB2
KCNJ16
KIFC3
LAPTM5
LATS1
LINC01198
LITAF
LUC7L2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K2
MAP3K3
MAP3K5
MAP4K5
MAPKAPK3
MARK2
MARK4
MLANA
MOB3A
MRPL19
MTMR4
MYCN
MYO15B
N4BP2
N4BP3
NDFIP1
NDFIP2
NFE2
NHP2
NSRP1
NUDT21
NUMB
PARP16
PAX7
PDGFRB
PIP5K1A
PIP5K1C
PKN2
PLK1
PLK2
PMEPA1
POLR1C
POLR2A
POLR2B
POLR2C
POLR2E
POLR2M
POLR3A
PRKG2
PRKX
PRPF8
PRR16
PRRG1
PRRG2
PSMD4
PYM1
RAC1
RAD51AP1
RAF1
RANBP10
RAP2A
RAPGEF2
RAPGEF6
RASGEF1A
RASL11B
RBCK1
RET
RFT1
RNF11
RNF7
RPAP2
RPAP3
RPL18A
RPS3A
RPS6KA3
RPS6KA4
RPS6KB1
RUNX1
RUVBL1
SAAL1
SAMSN1
SAV1
SCAMP3
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEPTIN9
SERTAD1
SFTPC
SGK1
SGK2
SH3KBP1
SHISA6
SHTN1
SIVA1
SLC23A2
SLC6A3
SMAD1
SMAD3
SMAD5
SMARCC1
SMO
SNCA
SP140L
SPANXN3
SPRY2
SRC
SRMS
SRSF7
STK24
STK25
STK26
STK31
STK4
SULF1
SYK
SYT1
TAF1B
TBC1D7
TBK1
TCEANC
TCP11L1
TEAD2
THOC1
THRAP3
TNIK
TOM1
TOM1L2
TP53BP2
TP73
TRIM44
TRIM52
TRPV6
TTYH2
UBAP2L
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2L3
UBE2M
UBOX5
URI1
VDAC2
VDAC3
WBP1
WBP2
WEE1
YES1
YOD1
42 interacting genes:
AR
ATN1
ATXN3
BCAP31
BCL2L1
BID
CARD16
CARD17
CARD8
CASP10
CASP14
CASP8
CAST
CDK11B
EGFR
FGF2
HTT
IL18
IL1A
IL1B
IL33
IL37
LMNA
MAPT
NEDD4
NFE2L2
NLRC4
NLRP1
NOD1
PAK1
PARP1
PLA2G4A
PLA2G4B
PRKN
PSEN1
PSEN2
PYCARD
RIPK2
SERPINB9
TFAP2A
TIRAP
VAC14
Entrez ID
4734
834
HPRD ID
03786
00977
Ensembl ID
ENSG00000069869
ENSG00000137752
Uniprot IDs
P46934
A8K249
A8K257
P29466
PDB IDs
2KPZ
2KQ0
2M3O
2XBB
2XBF
3B7Y
4BBN
4BE8
4N7F
4N7H
5AHT
5C7J
5C91
1BMQ
1IBC
1ICE
1RWK
1RWM
1RWN
1RWO
1RWP
1RWV
1RWW
1RWX
1SC1
1SC3
1SC4
2FQQ
2H48
2H4W
2H4Y
2H51
2H54
2HBQ
2HBR
2HBY
2HBZ
3D6F
3D6H
3D6M
3E4C
3NS7
5FNA
5MMV
5MTK
6BZ9
6F6R
6KN0
6PZP
6VIE
Enriched GO Terms of Interacting Partners
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