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NEDD4 and MAP3K5
Data Source:
BioGRID
(enzymatic study)
NEDD4
MAP3K5
Description
NEDD4 E3 ubiquitin protein ligase
mitogen-activated protein kinase kinase kinase 5
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Chromatin
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Cortex
Apicolateral Plasma Membrane
Protein-containing Complex
Dendritic Spine
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cytoplasm
Cytosol
External Side Of Plasma Membrane
Protein-containing Complex
Protein Kinase Complex
IRE1-TRAF2-ASK1 Complex
Molecular Function
Protein Binding
Sodium Channel Inhibitor Activity
Enzyme Binding
Protein Domain Specific Binding
Beta-2 Adrenergic Receptor Binding
Ubiquitin Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase Binding
Proline-rich Region Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Lysosome
Lysosomal Transport
Neuromuscular Junction Development
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Macroautophagy
Protein Ubiquitination
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Receptor Internalization
Receptor Catabolic Process
Cellular Response To UV
Regulation Of Ion Transmembrane Transport
Regulation Of Membrane Potential
Glucocorticoid Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Development Involved In Symbiotic Interaction
Positive Regulation Of Protein Catabolic Process
Viral Budding
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Progesterone Receptor Signaling Pathway
Response To Calcium Ion
Protein K63-linked Ubiquitination
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
MAPK Cascade
Activation Of MAPKK Activity
Response To Ischemia
Protein Phosphorylation
JNK Cascade
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Viral Process
Cellular Response To Stress
Cellular Response To Amino Acid Starvation
Response To Endoplasmic Reticulum Stress
P38MAPK Cascade
Wound Healing
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Stress-activated MAPK Cascade
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Hydrogen Peroxide
Cellular Response To Tumor Necrosis Factor
Endothelial Cell Apoptotic Process
Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Neuron Death
Cellular Response To Reactive Nitrogen Species
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways
ISG15 antiviral mechanism
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Oxidative Stress Induced Senescence
Oxidative Stress Induced Senescence
Drugs
Diseases
GWAS
Brain connectivity (
23471985
)
Chronic lymphocytic leukemia (
28165464
24292274
)
Dupuytren's disease (
28886342
)
Hip circumference adjusted for BMI (
28552196
)
Intraocular pressure (
29617998
)
Joint mobility (Beighton score) (
27182965
)
Keloid (
20711176
)
Refractive error (
32231278
)
Stroke (
29531354
)
Eosinophil counts (
32888494
)
HDL cholesterol (
30275531
)
HDL cholesterol levels (
32203549
)
Immature fraction of reticulocytes (
32888494
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
238 interacting genes:
ABCB1
ABL1
ABL2
ADRB2
AKT3
AMOT
AMOTL1
AMPD2
ANKRD13D
ANXA13
AP1G2
ARID1A
ASPSCR1
AURKC
BAIAP2
BMPR1A
BRCA2
CAD
CALCOCO1
CAMK1D
CAMK4
CAMKK2
CASP1
CASP3
CASP6
CASP7
CBLB
CCNH
CDC25C
CDK5
CDK5R1
CLIC2
CLK3
CPSF1
CPSF6
CUEDC1
DAZAP2
DCUN1D1
DDX3X
DDX54
DHX30
DIAPH1
DVL1
DYRK4
EBAG9
EGFR
EPHA5
EPRS1
EPS15
ERBB3
ERBB4
ERMN
ERRFI1
FES
FGF12
FGF21
FGFR1
FGFR2
FKBP3
FLT1
FLT4
FYN
GABARAP
GABARAPL1
GABARAPL2
GBA
GFUS
GRB10
GRIN2A
GRK4
GRK7
H3-3A
HGS
HMCES
HNRNPK
HNRNPL
HNRNPU
HNRNPUL1
IFITM3
IGF1R
IRS1
IRS2
JHY
JUN
KCNAB1
KCNAB2
KCNJ16
KIFC3
LAPTM5
LATS1
LINC01198
LITAF
LUC7L2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K2
MAP3K3
MAP3K5
MAP4K5
MAPKAPK3
MARK2
MARK4
MLANA
MOB3A
MRPL19
MTMR4
MYCN
MYO15B
N4BP2
N4BP3
NDFIP1
NDFIP2
NFE2
NHP2
NSRP1
NUDT21
NUMB
PARP16
PAX7
PDGFRB
PIP5K1A
PIP5K1C
PKN2
PLK1
PLK2
PMEPA1
POLR1C
POLR2A
POLR2B
POLR2C
POLR2E
POLR2M
POLR3A
PRKG2
PRKX
PRPF8
PRR16
PRRG1
PRRG2
PSMD4
PYM1
RAC1
RAD51AP1
RAF1
RANBP10
RAP2A
RAPGEF2
RAPGEF6
RASGEF1A
RASL11B
RBCK1
RET
RFT1
RNF11
RNF7
RPAP2
RPAP3
RPL18A
RPS3A
RPS6KA3
RPS6KA4
RPS6KB1
RUNX1
RUVBL1
SAAL1
SAMSN1
SAV1
SCAMP3
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEPTIN9
SERTAD1
SFTPC
SGK1
SGK2
SH3KBP1
SHISA6
SHTN1
SIVA1
SLC23A2
SLC6A3
SMAD1
SMAD3
SMAD5
SMARCC1
SMO
SNCA
SP140L
SPANXN3
SPRY2
SRC
SRMS
SRSF7
STK24
STK25
STK26
STK31
STK4
SULF1
SYK
SYT1
TAF1B
TBC1D7
TBK1
TCEANC
TCP11L1
TEAD2
THOC1
THRAP3
TNIK
TOM1
TOM1L2
TP53BP2
TP73
TRIM44
TRIM52
TRPV6
TTYH2
UBAP2L
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2L3
UBE2M
UBOX5
URI1
VDAC2
VDAC3
WBP1
WBP2
WEE1
YES1
YOD1
64 interacting genes:
AKT1
ARRB1
ARRB2
AURKA
CCND2
CDC25A
CDK4
CDK6
CDKN1A
CDKN2A
CREBBP
DAB2IP
DAXX
DMD
DUSP19
EIF2AK2
EP300
ERN1
FGFR4
FZR1
GADD45B
GEMIN5
GLIS2
GLRX
GSTM1
HSPA1A
IGF1R
JAK2
MAP2K4
MAP2K6
MAP2K7
MAP3K2
MAP3K3
MAP3K6
MAP3K7
MAPK8IP3
MBP
NEDD4
NEDD4L
NF2
PDCD6
PPP3R1
PPP5C
PTPN11
QARS1
RAF1
SFN
SIAH1
STK11
TEAD2
TERT
TNFAIP3
TNNT2
TPD52L1
TRAF2
TRAF5
TRAF6
TULP3
TXN
USP9X
YWHAE
YWHAH
YWHAQ
YWHAZ
Entrez ID
4734
4217
HPRD ID
03786
03904
Ensembl ID
ENSG00000069869
ENSG00000197442
Uniprot IDs
P46934
Q99683
PDB IDs
2KPZ
2KQ0
2M3O
2XBB
2XBF
3B7Y
4BBN
4BE8
4N7F
4N7H
5AHT
5C7J
5C91
2CLQ
3VW6
4BF2
4BHN
4BIB
4BIC
4BID
4BIE
5ULM
5UOR
5UOX
5UP3
5V19
5V24
5VIL
5VIO
6E2M
6E2N
6E2O
6EJL
6OYT
6OYW
6VRE
6XIH
Enriched GO Terms of Interacting Partners
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