ZFHX3 and COPS6

Data Source:
BioGRID (two hybrid)

		ZFHX3	COPS6
Description		zinc finger homeobox 3	COP9 signalosome subunit 6
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body	Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding	Protein Binding Metallopeptidase Activity Isopeptidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell Cycle Arrest Brain Development Muscle Organ Development Circadian Regulation Of Gene Expression Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Transforming Growth Factor Beta Regulation Of Locomotor Rhythm	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Viral Process Post-translational Protein Modification
Pathways		RUNX3 regulates CDKN1A transcription	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 28416822 30061737 29892015 19597491 19597492 22544366) Behavioural changes in frontotemporal lobe dementia ( 29724592) Body mass index ( 28892062 29273807) Brain morphology (MOSTest) ( 32665545) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Chronotype ( 30696823) Early onset atrial fibrillation ( 28460022) Estimated glomerular filtration rate ( 31152163 31015462 31451708) General risk tolerance (MTAG) ( 30643258) Glucocorticoid-induced osteonecrosis ( 26265699) Heel bone mineral density ( 30598549) Hypospadias ( 25108383) Incident atrial fibrillation ( 28416818) Ischemic stroke ( 29531354) Ischemic stroke (cardioembolic) ( 26708676 29531354) Kawasaki disease ( 19132087) LDL cholesterol ( 21347282) Lung function (FVC) ( 30061609) Metabolite levels ( 23823483 22916037) Morning person ( 30696823) Nose morphology ( 29921221) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Prevalent atrial fibrillation ( 28416818) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Stroke ( 29531354) Stroke (ischemic) ( 23041239) Type 2 diabetes ( 32499647)	Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		36 interacting genes: ALKBH4 AURKA BHLHE40 C11orf49 CEP70 CNOT2 COPS6 DEUP1 EFHC2 GOLGA2 GOLGA6L9 HIVEP1 KRT31 KRT34 KRT40 LMNB2 MSX2 MTUS2 MYB NINL PIAS3 PIBF1 PICK1 POU2F1 POU6F2 PRPF40A RBM11 SPECC1L TACC1 TLE5 TRIM27 TRIM54 TRIML2 TTC23 USHBP1 ZNF620	93 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS7B COPS8 COPS9 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHC3 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24
Entrez ID		463	10980
HPRD ID		00075	16735
Ensembl ID		ENSG00000140836	ENSG00000168090
Uniprot IDs		Q15911 Q8N2Y6	Q7L5N1
PDB IDs		2DA1 2DA2 2DA3	4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I
Enriched GO Terms of Interacting Partners?
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