COPS6 and ZEB2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COPS6	ZEB2
Description		COP9 signalosome subunit 6	zinc finger E-box binding homeobox 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Protein Binding Metallopeptidase Activity Isopeptidase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Phosphatase Regulator Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Viral Process Post-translational Protein Modification	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Anatomical Structure Development Regulation Of Catalytic Activity Melanocyte Migration Regulation Of Melanosome Organization
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases			Mowat-Wilson syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Adventurousness ( 30643258) Age-related nuclear cataracts ( 33311586) Childhood absence epilepsy ( 30531953) Chin dimples ( 27182965) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 30306274) Coronary artery disease ( 32469254 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 22949513) Hand grip strength ( 29691431) High myopia ( 31816047) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965 30899065) Red blood cell count ( 29403010) Refractive error ( 32231278) Renal cell carcinoma ( 23184150 25826619) Retinal detachment or retinal break ( 31816047) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 29483656 23974872) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)
Interacting Genes		93 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS7B COPS8 COPS9 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHC3 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24	11 interacting genes: APP CBX4 COPS6 CTBP1 CTBP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I
Entrez ID		10980	9839
HPRD ID		16735	05780
Ensembl ID		ENSG00000168090	ENSG00000169554
Uniprot IDs		Q7L5N1	O60315
PDB IDs		4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I	2DA7
Enriched GO Terms of Interacting Partners?
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