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MYC and MAPK3
Data Source:
HPRD
(in vitro)
MYC
MAPK3
Description
MYC proto-oncogene, bHLH transcription factor
mitogen-activated protein kinase 3
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Protein-containing Complex
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Pseudopodium
Protein-containing Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Activating Transcription Factor Binding
Protein-containing Complex Binding
Protein Dimerization Activity
Repressing Transcription Factor Binding
E-box Binding
Phosphotyrosine Residue Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Phosphatase Binding
Identical Protein Binding
Scaffold Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Mesenchymal Cell Proliferation
Energy Reserve Metabolic Process
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Cellular Iron Ion Homeostasis
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Notch Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Response To Gamma Radiation
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Oxygen Transport
Protein Deubiquitination
Cytokine-mediated Signaling Pathway
Regulation Of Telomere Maintenance
Negative Regulation Of Stress-activated MAPK Cascade
Protein-DNA Complex Disassembly
Cellular Response To UV
Cellular Response To Drug
Response To Drug
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Fibroblast Apoptotic Process
Negative Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Chromosome Organization
Negative Regulation Of Cell Division
Positive Regulation Of Telomerase Activity
ERK1 And ERK2 Cascade
Response To Growth Factor
Cellular Response To Hypoxia
Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation
Regulation Of Somatic Stem Cell Population Maintenance
Beta-catenin-TCF Complex Assembly
Positive Regulation Of DNA Methylation
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Response To DNA Damage Stimulus
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Positive Regulation Of Protein Phosphorylation
Transcription Initiation From RNA Polymerase I Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Induced Protein Phosphorylation
Cell Cycle
Cell Surface Receptor Signaling Pathway
Axon Guidance
Aging
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Chemotaxis
Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Phosphorylation
Peptidyl-serine Phosphorylation
Sensory Perception Of Pain
Arachidonic Acid Metabolic Process
Platelet Activation
Regulation Of Ossification
BMP Signaling Pathway
Regulation Of Cellular PH
Thyroid Gland Development
Positive Regulation Of Cyclase Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Histone Phosphorylation
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Outer Ear Morphogenesis
Response To Exogenous DsRNA
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Thymus Development
Regulation Of DNA-binding Transcription Factor Activity
Cartilage Development
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Positive Regulation Of Telomerase Activity
Bergmann Glial Cell Differentiation
Face Development
Lung Morphogenesis
Trachea Formation
Cardiac Neural Crest Cell Development Involved In Heart Development
Protein-containing Complex Assembly
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Interleukin-1-mediated Signaling Pathway
Response To Epidermal Growth Factor
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Positive Regulation Of Macrophage Proliferation
Regulation Of Cellular Response To Heat
Cellular Response To Dopamine
Positive Regulation Of Telomere Capping
Positive Regulation Of Xenophagy
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Apolipoprotein Binding
Pathways
Transcription of E2F targets under negative control by DREAM complex
NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Binding of TCF/LEF:CTNNB1 to target gene promoters
MAPK6/MAPK4 signaling
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
TFAP2 (AP-2) family regulates transcription of cell cycle factors
RUNX3 regulates WNT signaling
Estrogen-dependent gene expression
Transcriptional regulation of granulopoiesis
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Spry regulation of FGF signaling
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RNA Polymerase I Promoter Opening
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Growth hormone receptor signaling
Drugs
Acetylsalicylic acid
Nadroparin
Sulindac
Acetylsalicylic acid
Minocycline
Arsenic trioxide
Purvalanol
5-iodotubercidin
Seliciclib
Cholecystokinin
Ulixertinib
Diseases
Choriocarcinoma
Penile cancer
Burkitt lymphoma
Oral cancer
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Multiple myeloma
Small cell lung cancer
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Osteosarcoma
Kaposi's sarcoma
Laryngeal cancer
Breast cancer
Ovarian cancer
GWAS
Alcohol use disorder (
30940813
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
23817571
)
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
31036433
30929738
)
Bladder cancer (
20972438
)
Breast cancer (
29059683
23535729
)
Chronic lymphocytic leukemia (
23770605
)
Colorectal cancer (
25990418
26151821
24737748
23266556
)
Colorectal cancer or advanced adenoma (
30510241
)
Diffuse large B cell lymphoma (
25261932
)
Endometrial cancer (
30093612
27135401
)
Endometrial cancer (endometrioid histology) (
30093612
)
Endometrial endometrioid carcinoma (
27135401
)
Glioblastoma (
29743610
)
Glioma (
29743610
)
Height (
25429064
)
Multiple sclerosis (
21833088
)
Non-glioblastoma glioma (
29743610
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Ovarian cancer (
23535730
20852632
)
Pancreatic cancer (
29422604
27579533
25086665
)
Prostate cancer (
24753544
)
Prostate cancer (early onset) (
24740154
)
Prostate-specific antigen levels (
28139693
)
Prostate-specific antigen levels (conditioned on lead SNPs) (
28139693
)
Renal cell carcinoma (
24220699
)
Urinary bladder cancer (
20348956
18794855
24861552
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Childhood body mass index (
33045005
)
Hodgkin's lymphoma (
30194254
)
Multiple sclerosis (
31604244
24076602
)
Pubertal anthropometrics (
23449627
)
Schizophrenia (
28991256
25056061
29483656
)
Tonsillectomy (
27182965
28928442
)
Waist circumference (
28552196
)
Weight (
28552196
)
Interacting Genes
178 interacting genes:
ACTL6A
AKT1
APP
ARAF
ARNT
ATAD2
AURKA
AXIN1
BCL2
BIN1
BRCA1
BRD3
BTRC
CALM1
CBLC
CCAR2
CCNE1
CCNT1
CDC6
CDC73
CDCA7L
CDK1
CDK4
CDK6
CDK8
CDK9
CDKN1B
CDKN2A
CDKN2B
CDKN2C
CEBPA
CEBPB
CEP57
CIP2A
CREBBP
CSNK2A1
CSNK2A2
DACH1
DNMT3A
EFNB1
ELF3
EP300
EP400
EPHA2
ERBB2
FBXO8
FBXW7
FBXW8
FGFR4
FZR1
GCN1
GLIS1
GLIS2
GPX2
GRM1
GSK3A
GSK3B
GTF2F1
GTF2F2
GTF2I
HGF
HIF1A
HSP90AA1
ING4
KAT2A
KAT2B
KAT5
KDELR2
KDM1A
KIDINS220
LATS2
LDOC1
MAP2K1
MAP2K5
MAPK1
MAPK14
MAPK3
MAPK7
MAPK8
MAX
MDM2
MED1
MED16
MEN1
MET
MLH1
MOK
MSH2
MXD1
MXI1
MYCBP
MYCBP2
NDRG1
NEK11
NF2
NFIC
NFYB
NFYC
NMI
NONO
NOTCH3
NSD3
NUCB1
PAK2
PARP10
PDGFRA
PFDN5
PIK3CA
PLAU
PLK1
PML
PPP2CA
PRDX1
PSMC3
PTEN
RAF1
RASSF1
RB1
RBL1
RELA
RIOX2
RUVBL1
RUVBL2
SAP130
SENP2
SF3B1
SKP1
SKP2
SMAD2
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SNIP1
SNRNP70
SOX3
SOX4
SP1
SPAG9
STK11
SUPT3H
TADA2A
TAF12
TAF1B
TAF9
TBP
TEAD2
TERT
TFAP2A
TFAP2B
TIAM1
TONSL
TP53
TP73
TRIM55
TRIM6
TRIM63
TRRAP
TSC1
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
UBB
USP2
USP22
USP36
USP37
USP7
VDR
WT1
YAF2
YBX1
YY1
ZBTB17
ZNF281
186 interacting genes:
AKR1C1
AMOT
ARRB1
ATP1A1
AURKA
BCL2
BCL3
BRAF
BTBD10
BUB1
C1QBP
CASP8
CASP9
CAV1
CCDC6
CDC23
CDC25C
CDC45
CDH1
CDKN2A
CEBPB
CPXM1
CREBBP
CREM
CRP
CTNND1
CUEDC2
DAPK1
DCC
DCP1A
DLC1
DUSP1
DUSP10
DUSP3
DUSP4
DUSP5
DUSP6
DUSP9
EGFR
ELK1
ELK4
EPOR
ESR1
ETS1
ETV1
FBXW7
FCGR2B
FKBP2
FOS
FOXP2
FRS2
GAB1
GAB2
GATA1
GATA4
GJA1
GMFB
GRK2
GTF2I
HDAC4
HDAC6
HIF1A
HMMR
HNF4A
HSF1
HSF4
HSPB8
HTRA2
ID2
IER3
INSR
IRS1
ITGAV
ITGB3
JUN
JUND
KRT8
KSR2
L3MBTL3
LAMTOR3
LCK
LIPE
LRPAP1
LRRC4
LYN
MAFG
MAGEA11
MAGED1
MAP2K1
MAP2K2
MAP2K3
MAP3K14
MAPK14
MAPK8
MAPKAPK2
MAPT
MBP
MED1
METAP2
MKNK1
MYC
MYLK
MYOG
NAB2
NCKIPSD
NGFR
NRAS
NTRK1
NTRK3
NUP153
NUP58
PAK2
PDE6G
PDGFRL
PEA15
PFKM
PLAT
PLCB1
PPARA
PPP1CA
PPP2CA
PRKCD
PRKCE
PRKCZ
PTPN11
PTPN5
PTPN7
PTPRE
PTPRR
PXN
RAB4A
RAF1
RALGDS
RB1
RCAN1
RET
RNF114
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RXRA
SCAND1
SCRIB
SMAD2
SNCG
SORBS3
SOS1
SOX2
SP1
SPIB
SRC
SREBF1
SREBF2
STAR
STAT3
STAT5A
STK11
STMN1
STMN2
STUB1
SULT4A1
SYK
SYN1
SYNE2
TAL1
TAL2
TCF3
TGIF1
TH
TNFSF11
TOP2B
TP53
TRIM54
TSC2
TTYH3
UBE4B
UBTF
USP21
VDR
VPS52
ZC3HC1
ZNF219
ZNF7
Entrez ID
4609
5595
HPRD ID
01818
03479
Ensembl ID
ENSG00000136997
ENSG00000102882
Uniprot IDs
P01106
L7RXH5
P27361
Q9BWJ1
PDB IDs
1A93
1EE4
1MV0
1NKP
2A93
2OR9
4Y7R
5I4Z
5I50
6C4U
6E16
6E24
6G6J
6G6K
6G6L
2ZOQ
4QTB
6GES
Enriched GO Terms of Interacting Partners
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