MYC and FZR1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MYC	FZR1
Description		MYC proto-oncogene, bHLH transcription factor	fizzy and cell division cycle 20 related 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Protein-containing Complex	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Protein-containing Complex Binding Protein Dimerization Activity Repressing Transcription Factor Binding E-box Binding	Protein Binding Anaphase-promoting Complex Binding Ubiquitin Ligase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Energy Reserve Metabolic Process Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Notch Signaling Pathway Positive Regulation Of Cell Population Proliferation Response To Gamma Radiation Regulation Of Gene Expression Positive Regulation Of Gene Expression Oxygen Transport Protein Deubiquitination Cytokine-mediated Signaling Pathway Regulation Of Telomere Maintenance Negative Regulation Of Stress-activated MAPK Cascade Protein-DNA Complex Disassembly Cellular Response To UV Cellular Response To Drug Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Fibroblast Apoptotic Process Negative Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Epithelial Cell Proliferation Chromosome Organization Negative Regulation Of Cell Division Positive Regulation Of Telomerase Activity ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To Hypoxia Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Regulation Of Somatic Stem Cell Population Maintenance Beta-catenin-TCF Complex Assembly Positive Regulation Of DNA Methylation Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus	DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Cell Population Proliferation Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Division Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint Negative Regulation Of Cell Aging Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Pathways		Transcription of E2F targets under negative control by DREAM complex NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Binding of TCF/LEF:CTNNB1 to target gene promoters MAPK6/MAPK4 signaling Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry TFAP2 (AP-2) family regulates transcription of cell cycle factors RUNX3 regulates WNT signaling Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis	Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Acetylsalicylic acid Nadroparin
Diseases		Choriocarcinoma Penile cancer Burkitt lymphoma Oral cancer Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Multiple myeloma Small cell lung cancer Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Osteosarcoma Kaposi's sarcoma Laryngeal cancer Breast cancer Ovarian cancer
GWAS		Alcohol use disorder ( 30940813) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 31036433 30929738) Bladder cancer ( 20972438) Breast cancer ( 29059683 23535729) Chronic lymphocytic leukemia ( 23770605) Colorectal cancer ( 25990418 26151821 24737748 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diffuse large B cell lymphoma ( 25261932) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Glioblastoma ( 29743610) Glioma ( 29743610) Height ( 25429064) Multiple sclerosis ( 21833088) Non-glioblastoma glioma ( 29743610) Nonsyndromic cleft lip with cleft palate ( 28232668) Ovarian cancer ( 23535730 20852632) Pancreatic cancer ( 29422604 27579533 25086665) Prostate cancer ( 24753544) Prostate cancer (early onset) ( 24740154) Prostate-specific antigen levels ( 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Renal cell carcinoma ( 24220699) Urinary bladder cancer ( 20348956 18794855 24861552)	Red cell distribution width ( 32888494)
Interacting Genes		178 interacting genes: ACTL6A AKT1 APP ARAF ARNT ATAD2 AURKA AXIN1 BCL2 BIN1 BRCA1 BRD3 BTRC CALM1 CBLC CCAR2 CCNE1 CCNT1 CDC6 CDC73 CDCA7L CDK1 CDK4 CDK6 CDK8 CDK9 CDKN1B CDKN2A CDKN2B CDKN2C CEBPA CEBPB CEP57 CIP2A CREBBP CSNK2A1 CSNK2A2 DACH1 DNMT3A EFNB1 ELF3 EP300 EP400 EPHA2 ERBB2 FBXO8 FBXW7 FBXW8 FGFR4 FZR1 GCN1 GLIS1 GLIS2 GPX2 GRM1 GSK3A GSK3B GTF2F1 GTF2F2 GTF2I HGF HIF1A HSP90AA1 ING4 KAT2A KAT2B KAT5 KDELR2 KDM1A KIDINS220 LATS2 LDOC1 MAP2K1 MAP2K5 MAPK1 MAPK14 MAPK3 MAPK7 MAPK8 MAX MDM2 MED1 MED16 MEN1 MET MLH1 MOK MSH2 MXD1 MXI1 MYCBP MYCBP2 NDRG1 NEK11 NF2 NFIC NFYB NFYC NMI NONO NOTCH3 NSD3 NUCB1 PAK2 PARP10 PDGFRA PFDN5 PIK3CA PLAU PLK1 PML PPP2CA PRDX1 PSMC3 PTEN RAF1 RASSF1 RB1 RBL1 RELA RIOX2 RUVBL1 RUVBL2 SAP130 SENP2 SF3B1 SKP1 SKP2 SMAD2 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SNIP1 SNRNP70 SOX3 SOX4 SP1 SPAG9 STK11 SUPT3H TADA2A TAF12 TAF1B TAF9 TBP TEAD2 TERT TFAP2A TFAP2B TIAM1 TONSL TP53 TP73 TRIM55 TRIM6 TRIM63 TRRAP TSC1 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 UBB USP2 USP22 USP36 USP37 USP7 VDR WT1 YAF2 YBX1 YY1 ZBTB17 ZNF281	96 interacting genes: AKT1 AKT1S1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC5 ANAPC7 ARNT AURKA BECN1 BEX1 BLID BTRC BUB1B C7orf25 CCL5 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC20 CDC25A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2A CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PCLAF PDGFRA PLK1 PSMC3IP PTP4A3 PTTG1 RASSF1 RBBP8 SASS6 SENP2 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TEAD2 TERT THRSP TP53 UBE2C UBE2D1 UBE2D3 UBE2K UBE2S
Entrez ID		4609	51343
HPRD ID		01818	04687
Ensembl ID		ENSG00000136997	ENSG00000105325
Uniprot IDs		P01106	Q9UM11
PDB IDs		1A93 1EE4 1MV0 1NKP 2A93 2OR9 4Y7R 5I4Z 5I50 6C4U 6E16 6E24 6G6J 6G6K 6G6L	4UI9 5L9T 5L9U
Enriched GO Terms of Interacting Partners?
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