GET3 and APLN

Data Source:
BioGRID (pull down)

		GET3	APLN
Description		guided entry of tail-anchored proteins factor 3, ATPase	apelin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding	Signaling Receptor Binding Hormone Activity Apelin Receptor Binding Identical Protein Binding
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane	Angiogenesis Regulation Of The Force Of Heart Contraction Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Gastrulation Lactation Negative Regulation Of Gene Expression Viral Process Positive Regulation Of Heat Generation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Drinking Behavior Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Negative Regulation Of Vasoconstriction Positive Regulation Of Corticotropin Secretion Positive Regulation Of Corticotropin-releasing Hormone Secretion Apelin Receptor Signaling Pathway Coronary Vasculature Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		ATP
Diseases
GWAS
Interacting Genes		41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3	8 interacting genes: APLNR GET3 MDFI PLSCR4 PSMA3 RBPMS TRIM55 TRIM63
Entrez ID		439	8862
HPRD ID		03555	02246
Ensembl ID		ENSG00000198356	ENSG00000171388
Uniprot IDs		O43681	Q9ULZ1
PDB IDs		6SO5
Enriched GO Terms of Interacting Partners?
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