APLN and PLSCR4

Data Source:
BioGRID (two hybrid)

		APLN	PLSCR4
Description		apelin	phospholipid scramblase 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Apelin Receptor Binding Identical Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding
	Biological Process	Angiogenesis Regulation Of The Force Of Heart Contraction Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Gastrulation Lactation Negative Regulation Of Gene Expression Viral Process Positive Regulation Of Heat Generation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Drinking Behavior Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Negative Regulation Of Vasoconstriction Positive Regulation Of Corticotropin Secretion Positive Regulation Of Corticotropin-releasing Hormone Secretion Apelin Receptor Signaling Pathway Coronary Vasculature Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation	Plasma Membrane Phospholipid Scrambling Cellular Response To Lipopolysaccharide
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS			Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		8 interacting genes: APLNR GET3 MDFI PLSCR4 PSMA3 RBPMS TRIM55 TRIM63	62 interacting genes: ABHD17A ADAMTSL4 APLN ATP23 C11orf1 CES1 CLPP CRCT1 DAZAP2 DDIT4L EFEMP2 FCHO1 GATA1 HDHD3 HOXA1 INTS11 ITGB4 KLHL38 KPRP KRT82 KRTAP1-5 KRTAP10-8 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-1 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LCE1A LCE1C LCE2B LCE5A LPXN MTUS2 NID2 NOTCH2NLA OXER1 PCSK5 PLSCR1 RAMAC RBP3 RBPMS RPS27A SLC15A2 SSC4D TEKT5 TENM4 TRIM42 TRIP13 TSPAN4 UBA52 UBB UBC YPEL3 ZNF34
Entrez ID		8862	57088
HPRD ID		02246	07401
Ensembl ID		ENSG00000171388	ENSG00000114698
Uniprot IDs		Q9ULZ1	E9PHR9 Q9NRQ2
PDB IDs			3Q5U
Enriched GO Terms of Interacting Partners?
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