MMP14 and MMP2

Data Source:
HPRD (in vitro)

		MMP14	MMP2
Description		matrix metallopeptidase 14	matrix metallopeptidase 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton	Extracellular Region Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere Collagen-containing Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Zinc Ion Binding Metalloaminopeptidase Activity	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Response To Organic Cyclic Compound Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Craniofacial Suture Morphogenesis Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Embryo Implantation Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Tissue Remodeling Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus Cellular Response To UV-A Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs		Marimastat	Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin
Diseases			Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS		Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549 28869591) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)
Interacting Genes		35 interacting genes: ACAN ADI1 AQP6 BCAR1 C1QBP CAV1 CCL7 CLDN1 EBP ELOVL4 F11R F12 FHL3 FURIN HSD17B13 ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 MSMO1 PLLP RRAD SDC1 SPOCK1 SPOCK3 STOM TIMP2 TIMP3 TIMP4 TMEM31 ZUP1	39 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		4323	4313
HPRD ID		02856	00386
Ensembl ID		ENSG00000157227	ENSG00000087245
Uniprot IDs		P50281	A0A024R6R4 P08253
PDB IDs		1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?
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