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MMP14 and TMEM31
Data Source:
BioGRID
(two hybrid)
MMP14
TMEM31
Description
matrix metallopeptidase 14
transmembrane protein 31
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Extracellular Matrix
Cytoplasmic Vesicle
Melanosome
Macropinosome
Intermediate Filament Cytoskeleton
Integral Component Of Membrane
Molecular Function
Endopeptidase Activity
Metalloendopeptidase Activity
Integrin Binding
Protein Binding
Zinc Ion Binding
Metalloaminopeptidase Activity
Protein Binding
Biological Process
Skeletal System Development
Angiogenesis
Ovarian Follicle Development
Response To Hypoxia
Endothelial Cell Proliferation
Endochondral Ossification
Proteolysis
Response To Oxidative Stress
Male Gonad Development
Response To Mechanical Stimulus
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Protein Processing
Response To Organic Cyclic Compound
Protein Processing
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Positive Regulation Of Cell Growth
Lung Development
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Zymogen Activation
Endodermal Cell Differentiation
Chondrocyte Proliferation
Astrocyte Cell Migration
Response To Estrogen
Positive Regulation Of B Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Embryonic Cranial Skeleton Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Tissue Remodeling
Cell Motility
Negative Regulation Of Focal Adhesion Assembly
Head Development
Craniofacial Suture Morphogenesis
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Macrophage Migration
Response To Odorant
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Drugs
Marimastat
Diseases
GWAS
Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment (
32472697
)
Diastolic blood pressure (
30224653
)
Dupuytren's disease (
28886342
)
Heel bone mineral density (
30598549
28869591
)
Prostate cancer (
29892016
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Interacting Genes
35 interacting genes:
ACAN
ADI1
AQP6
BCAR1
C1QBP
CAV1
CCL7
CLDN1
EBP
ELOVL4
F11R
F12
FHL3
FURIN
HSD17B13
ITGAV
KASH5
KISS1
LRP1
LUM
MMP13
MMP2
MMP3
MSMO1
PLLP
RRAD
SDC1
SPOCK1
SPOCK3
STOM
TIMP2
TIMP3
TIMP4
TMEM31
ZUP1
141 interacting genes:
ABHD16A
ABHD5
AGPAT4
AGTRAP
ANKRD46
APOD
ARV1
ATP5MC3
ATP6V0C
BCAP31
BLCAP
BMP10
BNIP1
BTN2A2
C14orf180
C2CD2L
CAMLG
CCL4
CGRRF1
CLDND2
CLN5
CLRN1
CMTM7
CNIH3
COX14
COX20
CTSA
CTXN3
CXCL9
CXorf66
CYB561A3
CYB5R3
DEFB103A
DEFB103B
DEFB105A
DEFB105B
DERL1
DERL3
DGAT2L6
DHRSX
DNAJC30
EBP
EHHADH
EMP1
ERG28
FAXDC2
FCER1G
FKBP8
FXYD6
GIMAP5
GJB2
GJD4
GPR151
GUCA2A
GYPA
HERPUD2
HIGD1C
HSD17B13
HSD3B7
IFITM5
ITGAM
LHFPL5
LPAR3
LRAT
LY6D
MALL
MFSD14B
MMP14
MS4A1
NAT8
NINJ1
NINJ2
NSDHL
ORMDL2
OTOP3
OTULINL
PEDS1-UBE2V1
PLN
PLP1
PLP2
PMP22
PNLIPRP1
PTPN1
RDH11
REEP2
RETREG3
RNF144A
RNF19B
RTP2
SELENOK
SELENOM
SERP2
SGTA
SLC30A8
SLC35C2
SLC35E4
SLC39A6
SLC41A1
SLC66A2
SLC7A14
SMAGP
SMIM1
SMIM3
SMPD2
SNORC
SPTSSA
STX12
STX5
SYNGR1
TEX264
TIMMDC1
TMBIM6
TMEM107
TMEM121
TMEM14A
TMEM14C
TMEM182
TMEM203
TMEM208
TMEM218
TMEM239
TMEM242
TMEM254
TMEM255B
TMEM44
TMEM50A
TMEM86A
TMX2
TNFRSF10B
TRARG1
TSPAN2
TVP23B
UBE2J1
UBQLN1
UBQLN2
VAMP2
VAMP3
VAMP5
YIF1A
YIPF6
ZFPL1
Entrez ID
4323
203562
HPRD ID
02856
06652
Ensembl ID
ENSG00000157227
ENSG00000179363
Uniprot IDs
P50281
A0A140VK58
Q5JXX7
PDB IDs
1BQQ
1BUV
2MQS
3C7X
3MA2
3X23
4P3C
4P3D
4QXU
5H0U
6CLZ
6CM1
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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