MMP7 and CD151

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MMP7	CD151
Description		matrix metallopeptidase 7	CD151 molecule (Raph blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Matrix Extracellular Exosome	Basement Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Membrane
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding	Integrin Binding Protein Binding
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Aging Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Response To Nutrient Levels Estrous Cycle Maternal Process Involved In Female Pregnancy Cellular Response To Mechanical Stimulus	Cell Adhesion Viral Process Cell Migration Positive Regulation Of Cell Migration Hemidesmosome Assembly T Cell Proliferation Wound Healing, Spreading Of Cells Positive Regulation Of Endocytosis
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures Extra-nuclear estrogen signaling	Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly
Drugs		Marimastat (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID
Diseases			Nephropathy with pretibial epidermolysis bullosa and deafness
GWAS		Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Prostate cancer ( 23535732) Prostate-specific antigen levels ( 28139693)	Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494)
Interacting Genes		16 interacting genes: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11	12 interacting genes: ARL13B BCL7A GRAMD1C ITGA3 ITGA6 ITGB1 KLRC1 MMP7 PTGFRN RNF128 TMEM139 TSPAN18
Entrez ID		4316	977
HPRD ID		01525	03763
Ensembl ID		ENSG00000137673	ENSG00000177697
Uniprot IDs		P09237	A0A024RCB3 P48509 Q6ZNZ0
PDB IDs		1MMP 1MMQ 1MMR 2DDY 2MZE 2MZH 2MZI 2Y6C 2Y6D 5UE2 5UE5
Enriched GO Terms of Interacting Partners?
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