MMP7 and SPP1

Data Source:
HPRD (in vivo, in vitro)

		MMP7	SPP1
Description		matrix metallopeptidase 7	secreted phosphoprotein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding	Cytokine Activity Integrin Binding Protein Binding Extracellular Matrix Binding
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Aging Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Response To Nutrient Levels Estrous Cycle Maternal Process Involved In Female Pregnancy Cellular Response To Mechanical Stimulus	Osteoblast Differentiation Androgen Catabolic Process Inflammatory Response Cell Adhesion Signal Transduction Embryo Implantation Extracellular Matrix Organization Biomineral Tissue Development Response To Vitamin D Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Positive Regulation Of Estradiol Secretion
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures Extra-nuclear estrogen signaling	Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation
Drugs		Marimastat (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Prostate cancer ( 23535732) Prostate-specific antigen levels ( 28139693)	Blood protein levels ( 30072576) Dental caries ( 23064961) Urate levels ( 31578528)
Interacting Genes		16 interacting genes: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11	97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		4316	6696
HPRD ID		01525	01325
Ensembl ID		ENSG00000137673	ENSG00000118785
Uniprot IDs		P09237	A0A024RDE2 A0A024RDE6 A0A024RDJ0 B7Z351 P10451 Q3LGB0
PDB IDs		1MMP 1MMQ 1MMR 2DDY 2MZE 2MZH 2MZI 2Y6C 2Y6D 5UE2 5UE5	3CXD 3DSF
Enriched GO Terms of Interacting Partners?
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