MAP3K21 and MAP3K11

Data Source:
BioGRID (pull down, affinity chromatography technology)

		MAP3K21	MAP3K11
Description		mitogen-activated protein kinase kinase kinase 21	mitogen-activated protein kinase kinase kinase 11
Image
GO Annotations	Cellular Component	Cellular_component Cytoplasm	Cytoplasm Centrosome Microtubule Membrane
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation Signal Transduction Activation Of JUN Kinase Activity Protein Autophosphorylation	Activation Of MAPK Activity Protein Phosphorylation Microtubule-based Process JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways			RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			Fostamatinib
Diseases
GWAS			Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969)
Interacting Genes		4 interacting genes: CLK1 MAP3K10 MAP3K11 STUB1	27 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6
Entrez ID		84451	4296
HPRD ID		10087	02502
Ensembl ID		ENSG00000143674	ENSG00000173327
Uniprot IDs		Q5TCX8	A0A024R5E6 Q16584
PDB IDs		4UYA	5K26 5K28 6AQB 6CQ7
Enriched GO Terms of Interacting Partners?
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