MECP2 and SOX18

Data Source:
BioGRID (two hybrid)

		MECP2	SOX18
Description		methyl-CpG binding protein 2	SRY-box transcription factor 18
Image			No pdb structure
GO Annotations	Cellular Component	Heterochromatin Extracellular Space Nucleus Nucleoplasm Centrosome Cytosol Postsynapse	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Transcription Factor Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Protein Domain Specific Binding SiRNA Binding Protein N-terminus Binding Promoter-specific Chromatin Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Response To Hypoxia Startle Response Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inositol Metabolic Process Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Transcription Initiation From RNA Polymerase II Promoter Glutamine Metabolic Process Cellular Biogenic Amine Metabolic Process Mitotic Spindle Organization Synapse Assembly Respiratory Gaseous Exchange By Respiratory System Long-term Memory Protein Localization Glucocorticoid Metabolic Process Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Visual Learning Post-embryonic Development Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Dendrite Development Negative Regulation Of Angiogenesis Histone Methylation Histone Acetylation Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Cardiolipin Metabolic Process Social Behavior Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylcholine Metabolic Process Negative Regulation Of Smooth Muscle Cell Differentiation Response To Other Organism Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Positive Regulation Of Microtubule Nucleation Positive Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of DNA Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Vasculogenesis In Utero Embryonic Development Hair Follicle Development Vasculature Development Lymphangiogenesis Heart Looping Outflow Tract Morphogenesis Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Hair Cycle Process Cell Differentiation Embryonic Heart Tube Development Blood Vessel Endothelial Cell Migration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Stem Cell Fate Specification Endocardium Formation Lymphatic Endothelial Cell Differentiation Endocardial Cell Differentiation Establishment Of Endothelial Barrier Regulation Of Stem Cell Proliferation
Pathways
Drugs
Diseases		Non-syndromic X-linked mental retardation Rett syndrome Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)	Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS		Non-albumin protein levels ( 29403010) Red blood cell traits ( 23446634) Schizophrenia ( 24043878) Systemic lupus erythematosus ( 26663301 26502338 19838195)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: DNMT1 DNMT3L GTF2B H3C15 HDAC1 HIPK2 HMGB1 LBR NCOR1 PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1	5 interacting genes: AURKA GKAP1 HMGB1 MECP2 MEF2C
Entrez ID		4204	54345
HPRD ID		02050	07208
Ensembl ID		ENSG00000169057	ENSG00000203883
Uniprot IDs		A0A140VKC4 D3YJ43 P51608 Q59FJ6	P35713
PDB IDs		1QK9 3C2I 5BT2 6C1Y 6OGJ 6OGK
Enriched GO Terms of Interacting Partners?
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