MECP2 and PRPF40B

Data Source:
BioGRID (pull down, affinity chromatography technology)

		MECP2	PRPF40B
Description		methyl-CpG binding protein 2	pre-mRNA processing factor 40 homolog B
Image			No pdb structure
GO Annotations	Cellular Component	Heterochromatin Extracellular Space Nucleus Nucleoplasm Centrosome Cytosol Postsynapse	U1 SnRNP Nuclear Speck U2-type Prespliceosome
	Molecular Function	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Transcription Factor Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Protein Domain Specific Binding SiRNA Binding Protein N-terminus Binding Promoter-specific Chromatin Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Response To Hypoxia Startle Response Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inositol Metabolic Process Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Transcription Initiation From RNA Polymerase II Promoter Glutamine Metabolic Process Cellular Biogenic Amine Metabolic Process Mitotic Spindle Organization Synapse Assembly Respiratory Gaseous Exchange By Respiratory System Long-term Memory Protein Localization Glucocorticoid Metabolic Process Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Visual Learning Post-embryonic Development Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Dendrite Development Negative Regulation Of Angiogenesis Histone Methylation Histone Acetylation Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Cardiolipin Metabolic Process Social Behavior Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylcholine Metabolic Process Negative Regulation Of Smooth Muscle Cell Differentiation Response To Other Organism Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Positive Regulation Of Microtubule Nucleation Positive Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of DNA Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation	MRNA Splicing, Via Spliceosome MRNA Cis Splicing, Via Spliceosome
Pathways
Drugs
Diseases		Non-syndromic X-linked mental retardation Rett syndrome Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Non-albumin protein levels ( 29403010) Red blood cell traits ( 23446634) Schizophrenia ( 24043878) Systemic lupus erythematosus ( 26663301 26502338 19838195)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
Interacting Genes		19 interacting genes: DNMT1 DNMT3L GTF2B H3C15 HDAC1 HIPK2 HMGB1 LBR NCOR1 PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1	4 interacting genes: FUBP1 HLA-DRA HTT MECP2
Entrez ID		4204	25766
HPRD ID		02050	11044
Ensembl ID		ENSG00000169057	ENSG00000110844
Uniprot IDs		A0A140VKC4 D3YJ43 P51608 Q59FJ6	F8VU11 Q6NWY9
PDB IDs		1QK9 3C2I 5BT2 6C1Y 6OGJ 6OGK
Enriched GO Terms of Interacting Partners?
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