MDH2 and PC

Data Source:
HPRD (in vitro)

		MDH2	PC
Description		malate dehydrogenase 2	pyruvate carboxylase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	RNA Binding L-malate Dehydrogenase Activity Protein Self-association Malate Dehydrogenase (NADP+) Activity	Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADH Metabolic Process Aerobic Respiration	Pyruvate Metabolic Process Gluconeogenesis Lipid Metabolic Process Biotin Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Process
Pathways		Gluconeogenesis Citric acid cycle (TCA cycle)	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis
Drugs		NADH Citric acid Xanthinol	Pyruvic acid Biotin 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanal
Diseases			Pyruvate carboxylase deficiency
GWAS		Coffee consumption ( 31959922)	Bipolar disorder ( 21926972 31043756) Familial squamous cell lung carcinoma ( 29924316) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528)
Interacting Genes		8 interacting genes: CRYAB CS FH GOT2 HSPB1 NDUFS1 PC WARS1	3 interacting genes: GOT1 GOT2 MDH2
Entrez ID		4191	5091
HPRD ID		01099	02032
Ensembl ID		ENSG00000146701	ENSG00000173599
Uniprot IDs		A0A024R4K3 B3KTM1 G3XAL0 P40926	A0A024R5C5 P11498
PDB IDs		2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV	3BG3 3BG9
Enriched GO Terms of Interacting Partners?
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