MDH2 and FH

Data Source:
HPRD (in vitro)

		MDH2	FH
Description		malate dehydrogenase 2	fumarate hydratase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Tricarboxylic Acid Cycle Enzyme Complex Extracellular Exosome
	Molecular Function	RNA Binding L-malate Dehydrogenase Activity Protein Self-association Malate Dehydrogenase (NADP+) Activity	Fumarate Hydratase Activity Protein Binding
	Biological Process	Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADH Metabolic Process Aerobic Respiration	Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis
Pathways		Gluconeogenesis Citric acid cycle (TCA cycle)	Citric acid cycle (TCA cycle)
Drugs		NADH Citric acid Xanthinol
Diseases			Renal cell carcinoma Multiple cutaneous and uterine leiomyomata Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		Coffee consumption ( 31959922)	Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: CRYAB CS FH GOT2 HSPB1 NDUFS1 PC WARS1	17 interacting genes: C11orf49 CCDC102B CCDC57 CCNDBP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19
Entrez ID		4191	2271
HPRD ID		01099	00652
Ensembl ID		ENSG00000146701	ENSG00000091483
Uniprot IDs		A0A024R4K3 B3KTM1 G3XAL0 P40926	A0A0S2Z4C3 P07954
PDB IDs		2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV	3E04 5D6B 5UPP 6EBT
Enriched GO Terms of Interacting Partners?
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