MCM5 and ESCO2

Data Source:
BioGRID (pull down)

		MCM5	ESCO2
Description		minichromosome maintenance complex component 5	establishment of sister chromatid cohesion N-acetyltransferase 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane MCM Complex CMG Complex	Chromatin XY Body Nucleoplasm Chromosome Pericentric Heterochromatin Golgi Apparatus Chromocenter Cell Junction Site Of Double-strand Break
	Molecular Function	DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Single-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity	Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Acetyltransferase Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Duplex Unwinding	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Establishment of Sister Chromatid Cohesion
Drugs
Diseases			ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
GWAS		Chronotype ( 30696823) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		28 interacting genes: APP CDC5L CDC7 CDKN2A EP300 ESCO2 FBXO7 KRTAP10-7 LMNA MCM2 MCM3 MCM7 MCMBP MCPH1 MDFI NFKBIA NUDT3 ORC1 ORC2 ORC3 ORC5 ORC6 PTEN RBPMS RPA2 STAT1 TRIM28 YWHAG	12 interacting genes: FXR1 GOLGA2 MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA PICK1 RABEP1 SMC3
Entrez ID		4174	157570
HPRD ID		04075	18564
Ensembl ID		ENSG00000100297	ENSG00000171320
Uniprot IDs		B1AHB0 P33992	Q56NI9
PDB IDs		6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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