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TAOK1 and CSNK1E
Data Source:
BioGRID
(two hybrid)
TAOK1
CSNK1E
Description
TAO kinase 1
casein kinase 1 epsilon
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Microtubule Cytoskeleton
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Alpha-tubulin Binding
Protein Serine/threonine Kinase Activator Activity
Tau Protein Binding
Beta-tubulin Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Microtubule Cytoskeleton Organization
DNA Repair
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Microtubule Depolymerization
Mitotic G2 DNA Damage Checkpoint
Activation Of JUN Kinase Activity
Phosphorylation
Stress-activated Protein Kinase Signaling Cascade
Activation Of Protein Kinase Activity
Positive Regulation Of Stress-activated MAPK Cascade
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Neuron Projection Morphogenesis
Regulation Of Cytoskeleton Organization
Neuron Cellular Homeostasis
Regulation Of Microtubule Cytoskeleton Organization
Execution Phase Of Apoptosis
Positive Regulation Of Protein Acetylation
G2/M Transition Of Mitotic Cell Cycle
DNA Repair
Protein Phosphorylation
Endocytosis
Signal Transduction
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Ciliary Basal Body-plasma Membrane Docking
Regulation Of Cellular Protein Localization
Positive Regulation Of Wnt-mediated Midbrain Dopaminergic Neuron Differentiation
Positive Regulation Of Non-canonical Wnt Signaling Pathway
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
WNT mediated activation of DVL
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Circadian Clock
Anchoring of the basal body to the plasma membrane
Major pathway of rRNA processing in the nucleolus and cytosol
AURKA Activation by TPX2
Drugs
Fostamatinib
Seliciclib
Diseases
GWAS
Mean platelet volume (
22139419
24026423
19110211
19820697
32888494
22423221
27863252
)
Platelet count (
22139419
29066854
32888494
)
Red cell distribution width (
32888494
)
Keratoconus (
31855235
)
Interacting Genes
7 interacting genes:
C8orf33
CSNK1E
DYNC1I1
GEMIN7
MAP2K3
MARK1
WT1
55 interacting genes:
AKAP9
ANKRD6
APC
APP
ARHGEF1
ARNTL
AXIN1
AXIN2
BBS10
BHLHE41
BID
CADM4
CLOCK
CRY1
CSNK2B
DELEC1
DVL1
DVL2
DVL3
ENTR1
FAM110A
FAM110C
FAM83D
FBP1
FBXO7
FBXW11
GTF3C1
HES1
KAT7
MCC
NCOA3
NR1D2
PER1
PER2
PER3
PPP1CA
PPP1CC
PPP1R14A
PPP2R5D
PPP2R5E
PTPRD
RAD54B
RBX1
RORA
RORC
SOCS3
TAOK1
TAZ
TNS2
TRAF3
TRIM3
WDCP
ZMYND8
ZNF227
ZNF618
Entrez ID
57551
1454
HPRD ID
15467
02919
Ensembl ID
ENSG00000160551
ENSG00000213923
Uniprot IDs
A0A024QZ70
Q7L7X3
P49674
Q5U045
PDB IDs
4HNI
4HOK
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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