LSP1 and KLK6

Data Source:
BioGRID (two hybrid)

		LSP1	KLK6
Description		lymphocyte specific protein 1	kallikrein related peptidase 6
Image
GO Annotations	Cellular Component	Plasma Membrane Actin Cytoskeleton Membrane Extracellular Exosome	Extracellular Region Extracellular Space Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Secretory Granule
	Molecular Function	Actin Binding	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Cellular Defense Response Signal Transduction	Central Nervous System Development Response To Wounding Regulation Of Neuron Projection Development Protein Autoprocessing Collagen Catabolic Process Tissue Regeneration Hormone Metabolic Process Myelination Amyloid Precursor Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways
Drugs			Benzamidine
Diseases
GWAS		Bladder cancer ( 24163127) Breast cancer ( 29059683 17529967 23535729 27117709 20453838) Breast cancer (estrogen-receptor negative) ( 27117709) Celiac disease ( 23936387) Central corneal thickness ( 32528159) Diastolic blood pressure ( 27841878 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Granulocyte percentage of myeloid white cells ( 27863252) Hypertension ( 30487518) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte counts ( 32888494) Mammographic density (dense area) ( 25342443) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Methadone dose in opioid dependence ( 28115739) Milk allergy ( 25710614) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Potassium levels ( 29403010) Pulse pressure ( 27841878 30578418) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27841878 29403010 27618452 30487518 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908 21297633)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		10 interacting genes: ACTG1 BMPR2 GREB1 IL24 KLK6 LYPD3 MAPKAPK2 SCGB2A2 SNAI1 THRSP	7 interacting genes: LSP1 PALB2 PAX2 SERPINC1 SERPINF2 SNCA TSG101
Entrez ID		4046	5653
HPRD ID		01083	04037
Ensembl ID		ENSG00000130592	ENSG00000167755
Uniprot IDs		A8K7L8 P33241	A0A024R4J8 Q92876
PDB IDs		3BH8 4NO0 4NO2	1GVL 1L2E 1LO6 3VFE 4D8N 5NX1 5NX3 6QFF 6QFG 6QFH 6QH9 6QHA 6QHB 6QHC 6SKB 6SKC 6SKD
Enriched GO Terms of Interacting Partners?
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