KLK6 and SERPINF2

Data Source:
HPRD (in vitro)

		KLK6	SERPINF2
Description		kallikrein related peptidase 6	serpin family F member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Secretory Granule	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Central Nervous System Development Response To Wounding Regulation Of Neuron Projection Development Protein Autoprocessing Collagen Catabolic Process Tissue Regeneration Hormone Metabolic Process Myelination Amyloid Precursor Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Platelet Degranulation Acute-phase Response Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways			Platelet degranulation Dissolution of Fibrin Clot
Drugs		Benzamidine	Ocriplasmin Copper
Diseases			Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Blood protein levels ( 29875488) Calcium levels ( 24068962 20705733) Serum albumin level ( 23022100 29403010) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: LSP1 PALB2 PAX2 SERPINC1 SERPINF2 SNCA TSG101	17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		5653	5345
HPRD ID		04037	02029
Ensembl ID		ENSG00000167755	ENSG00000167711
Uniprot IDs		A0A024R4J8 Q92876	P08697
PDB IDs		1GVL 1L2E 1LO6 3VFE 4D8N 5NX1 5NX3 6QFF 6QFG 6QFH 6QH9 6QHA 6QHB 6QHC 6SKB 6SKC 6SKD
Enriched GO Terms of Interacting Partners?
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