LIMS1 and TMSB4X

Data Source:
HPRD (in vitro)

		LIMS1	TMSB4X
Description		LIM zinc finger domain containing 1	thymosin beta 4 X-linked
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Protein-containing Complex Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-containing Complex Binding	RNA Binding Actin Monomer Binding Protein Binding Enzyme Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Integrin-mediated Signaling Pathway	Platelet Degranulation Actin Filament Organization Cytoplasmic Sequestering Of NF-kappaB Regulation Of Cell Migration Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-8 Production Tumor Necrosis Factor-mediated Signaling Pathway Sequestering Of Actin Monomers Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Inflammatory Response Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proton-transporting ATP Synthase Activity, Rotational Mechanism Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of ATP Biosynthetic Process
Pathways		Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Platelet degranulation
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Beard thickness ( 26926045) Birth weight ( 31043758) Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045)	Asthma ( 30929738) Asthma (childhood onset) ( 30929738)
Interacting Genes		47 interacting genes: ADAMTS9 ATXN10 CATSPER1 CCN2 COL8A1 CSRP3 CWF19L2 DAPK1 EHMT2 FAM90A1 FERMT2 FERMT3 FMR1 GEM ILK INO80B IPO7 KPRP LMO3 LPXN MBIP MYO15B NCK2 NEB OSR2 PARVA PEG3 PLCE1 RAD51D RBBP8 RSU1 SCNM1 SMURF1 TBC1D22B TCEA2 TGFBR1 TMSB4X TRIO TTN USP11 ZIM2 ZMYM4 ZNF160 ZNF410 ZNF417 ZNF564 ZNF587	38 interacting genes: ACTA1 ACTA2 ACTB ACTG1 AKAP8L ALAS1 ANXA7 APLP1 CDKN1A COG6 FAM118B FHL3 GOLGA6L9 GRB7 HSF2BP IGSF21 ILK KRT13 KRT15 KRT31 KRT34 KRT36 KRT40 KRTAP8-1 LIMS1 PNMA1 PPP4C RAD21 RBPMS SCHIP1 SMN1 TAF1D TGM2 TK1 TRIM23 TRIM27 TRIP6 UHMK1
Entrez ID		3987	7114
HPRD ID		03978	02153
Ensembl ID		ENSG00000169756	ENSG00000205542
Uniprot IDs		P48059	A2VCK8 P62328 Q0P5T0
PDB IDs		1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q 4HI8 4HI9 6MIF	1UY5 3TU5 4PL7 4PL8
Enriched GO Terms of Interacting Partners?
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